Trypanosome mRNA recapping is triggered by hypermethylation originating from cap 4 [PDF]
journal ...
A Jesavel Iguchi +3 more
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Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing [PDF]
, 2019 Methylation of guanosine on position N7 (m7G) on internal RNA positions has been found in all domains of life and have been implicated in human disease.
Albrechtsen, Anders +5 more
core +2 more sources
Mechanisms and therapeutic potential of YTHDF readers: Linking epitranscriptomics to cancer
Journal of Pharmaceutical AnalysisYT521-B homology domain-containing family paralogs (YTHDFs), as RNA epigenetic modification effector proteins, fully or partially participate in N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 5-methylcytosine (m5C) modifications, which play ...
Na Deng +8 more
doaj +1 more source
RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts
MicroorganismsRNA modification is a key posttranscriptional process playing various biological roles, and one which has been reported to exist extensively in cellular RNAs.
Yingying Zou +3 more
doaj +1 more source
RNA modifications and their role in gene expression
Frontiers in Molecular BiosciencesPost-transcriptional RNA modifications have recently emerged as critical regulators of gene expression programs. Understanding normal tissue development and disease susceptibility requires knowledge of the various cellular mechanisms which control gene ...
I. Made Artika +4 more
doaj +1 more source
Identification and characterization of the RNA modifying factors PUS7 and WTAP as key components for the control of tumor biological processes in renal cell carcinomas [PDF]
Current research discusses the putative importance of RNA modification in tumor diseases. These RNA modifications include predominantly pseudouridinylation, ortho-methylations on the ribose residues, as well as methylations on the organic bases.
Dehghani, Faramarz +4 more
core +1 more source
Molecular Insights into RNA Modifications and their Role in Shaping Immune Responses and Tumor Microenvironments [PDF]
RNA modifications play crucial roles in immune system development and function, with dynamic changes essential for diverse cellular processes. Innovative profiling technologies are invaluable for understanding the significance of these modifications in ...
Ajmal, Tehreem +9 more
core +1 more source
Killing The Messenger: Exploring Novel Triggers For Messenger Rna Decay In Eukaryotes [PDF]
, 2017 The lifecycle of messenger RNAs is regulated by multiple layers beyond their primary sequence. In addition to carrying the information for protein synthesis, mRNAs are decorated with RNA binding proteins, marked with covalent chemical modifications, and ...
Vandivier, Lee Elliott
core +1 more source
Epitranscriptomic code and its alterations in human disease [PDF]
, 2018 Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modifications to date. These developments, together with the recent discovery of writers, readers, and erasers of modifications occurring across a wide range of ...
Janga, Sarath Chandra +1 more
core +1 more source
Nature CommunicationsWe leverage machine learning approaches to adapt nanopore sequencing basecallers for nucleotide modification detection. We first apply the incremental learning (IL) technique to improve the basecalling of modification-rich sequences, which are usually of
Ziyuan Wang +7 more
doaj +1 more source