Results 51 to 60 of about 4,176 (133)

Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers

Molecular Therapy: Nucleic Acids, 2021
As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA modification processes have been reported, and they are widely present in every organism and overall RNA type.
Dawei Rong, Guangshun Sun, Fan Wu, Ye Cheng, Guoqiang Sun, Wei Jiang, Xiao Li, Yi Zhong, Liangliang Wu, Chuanyong Zhang, Weiwei Tang, Xuehao Wang   +11 more
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset Analyses [PDF]

, 2022
We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most ...
Criner, Gerard J., Drummer, Charles, Jiang, Xiaohua, Kunapuli, Satya P., Li, Li, Liu, Ming, Lu, Yifan, Saaoud, Fatma, Shan, Huimin, Shao, Ying, Shao|, Sun, Yu, Sun, Yu, Sun|, Wang, Hong, Wang|, Wu, Sheng, XU, KEMAN, Xu|, Yang, Xiaofeng, Yang|, Zhang, Ruijing, Zhang|   +22 more
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Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation

Molecular Cancer, 2020
RNA modifications can be added or removed by a variety of enzymes that catalyse the necessary reactions, and these modifications play roles in essential molecular mechanisms.
Hanhan Shi, Peiwei Chai, Renbing Jia, Xianqun Fan   +3 more
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RNAME: A comprehensive database of RNA modification enzymes

Computational and Structural Biotechnology Journal, 2022
The dynamic RNA modifications were orchestrated by a series of enzymes, namely “writer”, “reader” and “eraser”, which can install, recognize and remove the modifications, respectively.
Fulei Nie, Qiang Tang, Ying Liu, Huaizhi Qin, Shilong Liu, Meng Wu, Pengmian Feng, Wei Chen   +7 more
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Targeted metabolomics analysis of nucleosides and the identification of biomarkers for colorectal adenomas and colorectal cancer [PDF]

, 2023
The morbidity and mortality of colorectal cancer (CRC) have been increasing in recent years, and early detection of CRC can improve the survival rate of patients. RNA methylation plays crucial roles in many biological processes and has been implicated in
Feiran Hu, Fuzhen Pan, Liuhao Lan, Meihui Xu, Mingwei Wang, Weifang Zheng, Xiaoyin Chai, Yingchen Wang, Zhe Zhang, Zhu Chen   +9 more
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m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Cell & Bioscience
Background N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong, Aiguo Xuan   +9 more
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ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells

Blood Science, 2020
. ALKBH3, a demethylase responsible for demethylating N1-methyladenosine (m1A) in mRNA and N1-methyldeoxyadenosine in single-stranded DNA, plays an important role in DNA repair and cancer cell proliferation.
Hanqing He, Yuqian Wang, Jianwei Wang
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RNA Modifications in Gastrointestinal Cancer: Current Status and Future Perspectives

Biomedicines, 2022
Gastrointestinal (GI) cancer, referring to cancers of the digestive system such as colorectal cancer (CRC), gastric cancer (GC), and liver cancer, is a major cause of cancer-related deaths in the world.
Xiaoting Zhang, Hao Su, Hongyan Chen, Qing Li, Xiaodong Liu, Lin Zhang, William Ka Kei Wu, Matthew Tak Vai Chan, Huarong Chen   +8 more
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WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science
N1‐methyladenosine (m1A) modification widely occurs in various RNAs, yet its pathophysiological function in tumorigenesis remains poorly understood. Notably, the expression and biological roles of tRNA m1A methyltransferase 6 noncatalytic subunit (TRMT6)
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
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RCAS: an RNA centric annotation system for transcriptome-wide regions of interest [PDF]

, 2017
In the field of RNA, the technologies for studying the transcriptome have created a tremendous potential for deciphering the puzzles of the RNA biology.
Akalin, A., Ohler, U., Rajewsky, N., Uyar, B., Wurmus, R., Yusuf, D.   +5 more
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