Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li +13 more
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Research progress of N1-methyladenosine RNA modification in cancer [PDF]
Cell Communication and SignalingN1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation.
Yafeng Liu +5 more
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Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine [PDF]
Frontiers in Cell and Developmental Biology, 2021 RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation.
Yating Xu +24 more
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Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer [PDF]
Frontiers in Immunology, 2021 Backgroundrecently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis.
Jinhui Liu +6 more
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N1-methyladenosine methylation-related metabolic genes signature and subtypes for predicting prognosis and immune microenvironment in osteosarcoma [PDF]
Frontiers in Genetics, 2022 N1-methyladenosine methylation (m1A), as an important RNA methylation modification, regulates the development of many tumours. Metabolic reprogramming is one of the important features of tumour cells, and it plays a crucial role in tumour development and
Guowei Wang +6 more
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N1-methyladenosine modification in cancer biology: Current status and future perspectives [PDF]
Computational and Structural Biotechnology Journal, 2022 Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and ...
Jiexin Li +2 more
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Gene Expression Profile of RNA N1-methyladenosine methyltransferases [PDF]
E3S Web of Conferences, 2020 N1-methyladenosine (m1A) is a kind of common and abundant methylation modification in eukaryotic mRNA and long-chain non-coding RNA. Nucleoside methyltransferase (MTase) of m1A is a diverse protein family, which is characterized by the presence of ...
Rao Mingzhu
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Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA [PDF]
Genomics, Proteomics & Bioinformatics, 2018 More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
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The metabolites for muscle and osteoclast activity are indicators of femoral neck osteoporosis [PDF]
Scientific ReportsFemoral neck osteoporosis is a critical risk factor for a bedbound state, which significantly decreases overall life expectancy, if a patient falls and suffers a fracture.
Masahiro Kameda +2 more
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RNA modifications in peripheral blood are associated with acute coronary syndrome [PDF]
Journal of Molecular and Cellular Cardiology PlusAcute coronary syndromes (ACS) trigger inflammatory and immune reactions, yet whether this response is associated with changes in RNA modifications remains poorly understood.
Miron Sopic +10 more
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