Advanced ScienceN1‐methyladenosine (m1A) modification widely occurs in various RNAs, yet its pathophysiological function in tumorigenesis remains poorly understood. Notably, the expression and biological roles of tRNA m1A methyltransferase 6 noncatalytic subunit (TRMT6)
Yuqing Lei +12 more
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Integrated Analysis of N1-Methyladenosine Methylation Regulators-Related lncRNAs in Hepatocellular Carcinoma. [PDF]
Cancers (Basel), 2023 N1-methyladenosine (m1A) and long non-coding RNAs (lncRNAs) play significant roles in tumor progression in hepatocellular carcinoma (HCC). However, their association with HCC is still unclear. In this study, lncRNAs related to m1A were extracted from the mRNA expression matrix in The Cancer Genome Atlas (TCGA) database.
Song D +6 more
europepmc +3 more sources
RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma. [PDF]
Front Immunol, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer Genome Atlas) and CGGA (Chinese Glioma Genome Atlas) cohorts. The differences in survival prognosis
Mao M, Chu Q, Lou Y, Lv P, Wang LJ.
europepmc +4 more sources
Establishment of a N1-methyladenosine-related risk signature for breast carcinoma by bioinformatics analysis and experimental validation. [PDF]
Breast Cancer, 2023 AbstractObjectivesBreast carcinoma (BRCA) has resulted in a huge health burden globally. N1-methyladenosine (m1A) RNA methylation has been proven to play key roles in tumorigenesis. Nevertheless, the function of m1A RNA methylation-related genes in BRCA is indistinct.MethodsThe RNA sequencing (RNA-seq), copy-number variation (CNV), single-nucleotide ...
Li L +5 more
europepmc +3 more sources
Deprotection of N1-methyladenosine-containing RNA using triethylamine hydrogen fluoride. [PDF]
Nucleosides Nucleotides Nucleic AcidsThe N1-methyladenosine (m1A) epigenetic modification exists in many RNAs and is related to many human diseases. Chemically synthesized RNAs containing the modification are required for projects aimed at studying biological processes, mechanisms, and pathogenesis related to m1A.
Apostle A, Fang S.
europepmc +3 more sources
ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17. [PDF]
Acta Pharm Sin B, 2023 Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development remains unclear.
Zhang J +11 more
europepmc +4 more sources
N1-Methyladenosine-Related lncRNAs Are Potential Biomarkers for Predicting Prognosis and Immune Response in Uterine Corpus Endometrial Carcinoma. [PDF]
Oxid Med Cell Longev, 2022 Uterine corpus endometrial carcinoma (UCEC) is a malignant disease that, at present, has no well‐characterised prognostic biomarker. In this study, two clusters were identified based on 28 N1‐methyladenosine‐ (m1A‐) related long noncoding RNAs (lncRNAs), of which cluster 1 was related to immune pathways according to the results of an enrichment ...
Liu J +7 more
europepmc +3 more sources
N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization. [PDF]
Front Cardiovasc Med, 2022 ObjectivesThis study aimed to identify key AAA-related m1A RNA methylation regulators and their association with immune infiltration in AAA. Furthermore, we aimed to explore the mechanism that m1A regulators modulate the functions of certain immune cells as well as the downstream target genes, participating in the progression of AAA.MethodsBased on the
Wu Y +12 more
europepmc +4 more sources
Integrative analysis of bulk and single-cell RNA sequencing data reveals distinct subtypes of MAFLD based on N1-methyladenosine regulator expression. [PDF]
Liver Res, 2023 Metabolic dysfunction-associated fatty liver disease (MAFLD) is now the most prevalent chronic liver disease worldwide, with an increasing incidence rate. MAFLD is a heterogeneous disease that can have a low or high-risk profile for developing severe liver disease in its natural course.
He J, Xiao C, Li C, Yang F, Du C.
europepmc +4 more sources
N1-Methyladenosine detection with CRISPR-Cas13a/C2c2. [PDF]
Chem Sci, 2019 CRISPR Cas13a provided a robust, simple and fluorescence-based method for m1A detection and dynamic m1A demethylation analysis of 28S rRNA.
Chen Y +8 more
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