Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA. [PDF]
Nat Methods, 2019 Chemical modifications to messenger RNA are increasingly recognized as a critical regulatory layer in the flow of genetic information, but quantitative tools to monitor RNA modifications in a whole-transcriptome and site-specific manner are lacking.
Zhou H +8 more
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The N1‐methyladenosine methyltransferase TRMT61A promotes bladder cancer progression and is targetable by small molecule compounds [PDF]
Clinical and Translational MedicineJianjian Yin +13 more
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MFAP2, upregulated by m1A methylation, promotes colorectal cancer invasiveness via CLK3
Cancer Medicine, 2023 Background Distant metastasis is the main cause of mortality in colorectal cancer (CRC) patients. N1‐methyladenosine (m1A) is a type of epitranscriptome modification.
Meng Xue +6 more
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Sequencing methods and functional decoding of mRNA modifications
Fundamental Research, 2023 More than 160 types of post-transcriptional RNA modifications have been reported; there is substantial variation in modification type, abundance, site, and function across species, tissues, and RNA type.
Kai Li, Jinying Peng, Chengqi Yi
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The Arabidopsis TRM61/TRM6 complex is a bona fide tRNA N1-methyladenosine methyltransferase. [PDF]
J Exp Bot, 2020 Abstract tRNA molecules, which contain the most abundant post-transcriptional modifications, are crucial for proper gene expression and protein biosynthesis. Methylation at N1 of adenosine 58 (A58) is critical for maintaining the stability of initiator methionyl-tRNA (tRNAiMet) in bacterial, archaeal, and eukaryotic tRNAs.
Tang J +5 more
europepmc +3 more sources
Dynamic regulation and key roles of ribonucleic acid methylation
Frontiers in Cellular Neuroscience, 2022 Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs ...
Jia Zou +14 more
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Research progress on mRNA methylation and diseases [PDF]
Jichu yixue yu linchuang, 2021 mRNA methylation modification, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A), etc., represents more than 60% of all mRNA modifications and varies distribution on mRNA.
LI Ran, HAO Yan-lei
doaj
Nature Communications, 2022 RNA modifications are important regulators of RNA biology. Here we report N1-methyladenosine (m1A) enrichment on 22-nucleotide tRNA fragments and its effect on gene-silencing.
Zhangli Su +6 more
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Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
Frontiers in Genetics, 2022 As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate.
Hui-Ming Chen +9 more
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Selektive Charakterisierung von N1-Methyladenosin neben N7-Methylguanosin im Harn [PDF]
cclm, 1981 We describe the selective analysis of N-methylated ribonucleosides, i.e., N1-methyl adenosine (m1Ado) and N7-methyl guanosine (m7Guo) in the presence of other nucleosides in urine. m1Ado as well as m7Guo were characterized by use of chromatographic techniques including substance specific chemical reactions.
Schlimme, E., Boos, K.-S., Weise, M.
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