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Clinician's Guide to Epitranscriptomics: An Example of N1-Methyladenosine (m1A) RNA Modification and Cancer. [PDF]
Life (Basel)Epitranscriptomics is the study of modifications of RNA molecules by small molecular residues, such as the methyl (-CH3) group. These modifications are inheritable and reversible. A specific group of enzymes called “writers” introduces the change to the RNA; “erasers” delete it, while “readers” stimulate a downstream effect.
Kvolik Pavić A +4 more
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Recent Advances in Identification of RNA Modifications
Non-Coding RNA, 2016 RNA modifications are involved in a broad spectrum of biological and physiological processes. To reveal the functions of RNA modifications, it is important to accurately predict their positions.
Wei Chen, Hao Lin
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N1-methyladenosine methylation in mRNAs drives bladder cancer progression
, 2023 Abstract With the growing recognition of RNA modification as a hallmark of cancer, N1-methyladenosine (m1A) methylation has been reported as a key mechanism of post-transcriptional regulation. However, the molecular mechanisms underlying m1A modification in bladder cancer (BLCA) progression remain unclear.
Dongkui Song +13 more
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Nature Communications, 2023 Internal modifications of mRNA have emerged as widespread and versatile regulatory mechanism to control gene expression at the post-transcriptional level.
Katja Hartstock +8 more
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Research Progress of RNA Methylation Modification in Colorectal Cancer
Frontiers in Pharmacology, 2022 Accumulating evidence indicates that RNA methylation, as the most common modification of mRNA, is of great significance in tumor progression and metastasis.
Weizheng Liang +6 more
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Landscape of
Cancer Reports, 2023 AbstractBackgroundN1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).AimsThe landscape of m1A modification patterns regarding tumor immune microenvironment (TIME) in CRC is a lack of knowledge.
Chun JIANG +4 more
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Frontiers in Bioscience-Landmark, 2022 Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators. There are several m1A regulators existing in the human genome, including YTHDF1-3 and YTHDC1.
Jia-Hui Yao +6 more
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RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis
Nature Communications, 2018 Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the ...
Uwe Richter +9 more
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The N1-Methyladenosine Methylome of Petunia mRNA [PDF]
Plant Physiology, 2020 N1-methyladenosine is a unique type of base methylation in that it blocks Watson-Crick base pairing and introduces a positive charge. m1A is prevalent in yeast and mammalian mRNA and plays a functional role. However, little is known about the abundance, dynamics, and topology of this modification in plant mRNA.
Weiyuan Yang +6 more
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The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
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