Results 101 to 110 of about 19,553 (185)

Evaluation of antidiphtheria toxin nanobodies

Nanotechnology, Science and Applications, 2010
Nanobodies are the smallest fragments of naturally occurring single-domain antibodies that have evolved to be fully functional in the absence of a light chain. Conventional antibodies are glycoproteins comprising two heavy and two light chains. Surprisingly, all members of the Camelidae family possess a fraction of antibodies devoid of both light ...
openaire   +5 more sources

Modulating ion channels with nanobodies

Synthetic and Systems Biotechnology
Ion channels play instrumental roles in regulating membrane potential and cross-membrane signal transduction, thus making them attractive targets for understanding various physiological processes and associated diseases. Gaining a deeper understanding of their structural and functional properties has significant implications for developing therapeutic ...
Sher Ali, Ashley Suris, Yun Huang, Yubin Zhou   +3 more
openaire   +3 more sources

Ultrapotent Broadly Neutralizing Human‐llama Bispecific Antibodies against HIV‐1

Advanced Science
Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal.
Jianliang Xu, Tongqing Zhou, Krisha McKee, Baoshan Zhang, Cuiping Liu, Alexandra F. Nazzari, Amarendra Pegu, Chen‐Hsiang Shen, Jordan E. Becker, Michael F. Bender, Payton Chan, Anita Changela, Ridhi Chaudhary, Xuejun Chen, Tal Einav, Young Do Kwon, Bob C. Lin, Mark K. Louder, Jonah S. Merriam, Nicholas C. Morano, Sijy O'Dell, Adam S. Olia, Reda Rawi, Ryan S. Roark, Tyler Stephens, I‐Ting Teng, Emily Tourtellott‐Fogt, Shuishu Wang, Eun Sung Yang, Lawrence Shapiro, Yaroslav Tsybovsky, Nicole A. Doria‐Rose, Rafael Casellas, Peter D. Kwong   +33 more
doaj   +1 more source

Nanobodies – effektive Immunwaffen gegen Krebs

BIOspektrum
Abstract Recently, we attached a nanobody targeting the cancer-relevant protein Survivin to ultrasmall gold nanoparticles. This enabled intracellular uptake, Survivin crosslinking, and interference with cancer cell mitosis. Coupling nanobodies to nanosized scaffolds is universally applicable to improve the function and therapeutic potential ...
Knauer, Shirley, Blüggel, Mike
openaire   +1 more source

Monovalent, bivalent and biparatopic nanobodies targeting S1 protein of porcine epidemic diarrhea virus efficiently neutralized the virus infectivity

BMC Veterinary Research
Background Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that causes severe diarrhea and death in neonatal piglets, which has brought huge economic losses to the pork industry worldwide since its first discovery in the early ...
Huai-rui Qin, Zhi Cao, Feng-zhe Lu, Wei Wang, Wenhui Zhao, Guimei Li, Hongliang Zhang, Shubai Wang, Zhihua Qin   +8 more
doaj   +1 more source

Exploring Trop-2-Nanobody PPI Interactions through Molecular Dynamics Simulations and Biovalidations. [PDF]

ACS Omega
Cheng J, Sun ZY, Guo Z, Hao Y, Hou G, Li Y, Wang Y, Feng Z, Xue Y, Meng L.   +9 more
europepmc   +1 more source

Camelid-Derived Nanobodies Targeting Human Epidermal Growth Factor Receptor: Screening, Expression, and Functional Validation. [PDF]

Antibodies (Basel)
Liu Y, Huang Q, Zhang D, Wang Y, Zhao S, Wen J, Kong Y, Xu J.   +7 more
europepmc   +1 more source

Tiny tools closing the gap: nanobodies in research and therapy. [PDF]

Function (Oxf)
Abdellatif M, Rajurkar J, Leonhardt H.
europepmc   +1 more source

Long-term live-cell microscopy with labeled nanobodies delivered by laser-induced photoporation

, 2020
Boukherroub, Rabah, Braeckmans, Kevin, Brans, Toon, De Keersmaecker, Herlinde, De Smedt, Stefaan, De Vos, Winnok H., Gettemans, Jan, Hebbrecht, Tim, Li, Chengnan, Lippens, Saskia, Liu, Jing, Parthoens, Eef, Xiong, Ranhua   +12 more
core   +1 more source

Pfs48/45 nanobodies block Plasmodium falciparum transmission. [PDF]

PLoS Pathog
Lyons FMT, Chmielewski J, Gabriela M, Chan LJ, Tong J, Adair A, Zeglinski K, Gouil Q, Dietrich MH, Tham WH.   +9 more
europepmc   +1 more source