Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2
iScience, 2022 Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease.
Phillip Pymm +23 more
doaj +1 more source
Spontaneous emission of an atom placed near a nanobelt of elliptical cross-section [PDF]
, 2007 Spontaneous emission of an atom (molecule) placed near a nanocylinder of elliptical cross-section of an arbitrary composition is studied. The analytical expressions have been obtained for the radiative and nonradiative channels of spontaneous decay and ...
B. Z. Katsenelenbaum +21 more
core +2 more sources
Applying antibodies inside cells: Principles and recent advances in neurobiology, virology and oncology [PDF]
, 2020 To interfere with cell function, many scientists rely on methods that target DNA or RNA due to the ease with which they can be applied. Proteins are usually the final executors of function but are targeted only indirectly by these methods.
Marschall, Andrea +4 more
core +1 more source
Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor. [PDF]
, 2017 About 50% of the world's arable land is strongly acidic (pH ≤ 5). The low pH solubilizes root-toxic ionic aluminium (Al3+) species from clay minerals, driving the evolution of counteractive adaptations in cultivated crops.
Chang, Geoffrey +6 more
core +3 more sources
Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]
, 2020 Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy +11 more
core +2 more sources
Nanobody-Displaying Flagellar Nanotubes [PDF]
Scientific Reports, 2018 AbstractIn this work we addressed the problem how to fabricate self-assembling tubular nanostructures displaying target recognition functionalities. Bacterial flagellar filaments, composed of thousands of flagellin subunits, were used as scaffolds to display single-domain antibodies (nanobodies) on their surface.
Ágnes Klein +6 more
openaire +3 more sources
Nanobodies as molecular imaging probes
Free Radical Biology and Medicine, 2022 Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies (Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their desirable properties such as small size, high specificity, strong affinity, excellent stability, and modularity, nanobodies are on their way to overtake conventional antibodies in
Sarah Barakat +4 more
openaire +4 more sources
A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles [PDF]
, 2016 Survivin, the smallest member of the inhibitor of apoptosis protein family, plays a central role during mitosis and exerts a cytoprotective function. Survivin is highly expressed in most cancer types and contributes to multiple facets of carcinogenesis ...
Beghein, Els +5 more
core +2 more sources
Nanobody-dependent delocalization of endocytic machinery in Arabidopsis root cells dampens their internalization capacity [PDF]
, 2020 Plant cells perceive and adapt to an ever-changing environment by modifying their plasma membrane (PM) proteome. Whereas secretion deposits new integral membrane proteins, internalization by endocytosis removes membrane proteins and associated ligands ...
De Meyer, Andreas +4 more
core +2 more sources
Revolutionizing antiviral therapy with nanobodies: Generation and prospects
Biotechnology Reports, 2023 As the world continues to grapple with infectious diseases, scientists are constantly searching for effective ways to combat these deadly pathogens. One promising avenue of research is the use of nanobodies as neutralization agents. These small proteins,
Mujahed I. Mustafa, Ahmed Mohammed
doaj +1 more source