Results 41 to 50 of about 19,553 (185)

Exploring cellular biochemistry with nanobodies [PDF]

Journal of Biological Chemistry, 2020
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the exploration of biology and in their ultimate application to medicine. Besides ligands for receptors of known specificity, agents commonly used for this purpose are monoclonal antibodies derived from mice, rabbits, and other animals.
Cheloha, Ross W, Harmand, Thibault J, Wijne, Charlotte, Schwartz, Thomas U, Ploegh, Hidde L   +4 more
openaire   +2 more sources

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Magez, Stefan, Stijlemans, Benoit   +2 more
core   +2 more sources

Institute collection and analysis of Nanobodies (iCAN): a comprehensive database and analysis platform for nanobodies

BMC Genomics, 2017
Background Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae.
Jing Zuo, Jian Li, Rongxin Zhang, Longsheng Xu, Hanhan Chen, Xiaohuan Jia, Zhipeng Su, Linhong Zhao, Xing Huang, Wei Xie   +9 more
doaj   +1 more source

Seed-produced anti-globulin VHH-Fc antibodies retrieve globulin precursors in the insoluble fraction and modulate the Arabidopsis thaliana seed subcellular morphology [PDF]

, 2020
Key message Nanobody-heavy chain (VHH-Fc) antibody formats have the potential to immunomodulate even highly accumulating proteins and provide a valuable tool to experimentally modulate the subcellular distribution of seed storage proteins.
Altmann, Friedrich, Arcalis, Elsa, De Meyer, Thomas, Depicker, Anna, Maleux, Katrien, Melnik, Stanislav, Nolf, Jonah, Stöger, Eva   +7 more
core   +2 more sources

Nanobodies as modulators of inflammation: potential applications for acute brain injury

Frontiers in Cellular Neuroscience, 2014
Nanobodies are single domain antibodies derived from llama heavy-chain only antibodies (HCAbs). They represent a new generation of biologicals with unique properties: nanobodies show excellent tissue distribution, high temperature and pH stability, are ...
Björn eRissiek, Friedrich eKoch-Nolte, Tim eMagnus   +2 more
doaj   +1 more source

Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis

MicrobiologyOpen, 2022
Necrotic enteritis (NE), caused by Clostridium perfringens, is an intestinal disease with devastating economic losses to the poultry industry. NE is a complex disease and predisposing factors that compromise gut integrity are required to facilitate C ...
Dharanesh Gangaiah, Valerie Ryan, Daphne Van Hoesel, Shrinivasrao P. Mane, Enid T. Mckinley, Nallakannu Lakshmanan, Nandakumar D. Reddy, Edward Dolk, Arvind Kumar   +8 more
doaj   +1 more source

Applications of nanobodies in brain diseases

Frontiers in Immunology, 2022
Nanobodies are antibody fragments derived from camelids, naturally endowed with properties like low molecular weight, high affinity and low immunogenicity, which contribute to their effective use as research tools, but also as diagnostic and therapeutic ...
Fang Zheng, Yucheng Pang, Luyao Li, Yuxing Pang, Jiaxin Zhang, Xinyi Wang, Geert Raes, Geert Raes   +7 more
doaj   +1 more source

Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection [PDF]

, 2019
Lower respiratory tract infections, such as infections caused by influenza A viruses, are a constant threat for public health. Antivirals are indispensable to control disease caused by epidemic as well as pandemic influenza A.
Ballegeer, Marlies, Creytens, Sarah, De Vlieger, Dorien, Hengel, Hartmut, Hoffmann, Katja, Nerinckx, Wim, Remaut, Han, Saelens, Xavier, Schepens, Bert, Van Hoecke, Lien, Van Molle, Inge   +10 more
core   +2 more sources

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Antibody RING-Mediated Destruction of Endogenous Proteins [PDF]

, 2020
International ...
Abidi, Naima, Dickerson, David, Hay, Ronald T., Ibrahim, Adel F. M., Prescott, Alan R., Shen, Linnan, Tatham, Michael H., Xirodimas, Dimitris P.   +7 more
core   +4 more sources