Results 61 to 70 of about 19,553 (185)

Development of Nanobodies Against Hemorrhagic and Myotoxic Components of Bothrops atrox Snake Venom

Frontiers in Immunology, 2020
Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites.
Henri Bailon Calderon, Verónica Olga Yaniro Coronel, Verónica Olga Yaniro Coronel, Omar Alberto Cáceres Rey, Elizabeth Gaby Colque Alave, Walter Jhon Leiva Duran, Carlos Padilla Rojas, Harrison Montejo Arevalo, David García Neyra, Marco Galarza Pérez, César Bonilla, Benigno Tintaya, Giulia Ricciardi, Natalia Smiejkowska, Ema Romão, Cécile Vincke, Juan Lévano, Mary Celys, Bruno Lomonte, Serge Muyldermans   +19 more
doaj   +1 more source

Iterative In Silico Screening for Optimizing Stable Conformation of Anti-SARS-CoV-2 Nanobodies

Pharmaceuticals
Nanobodies (Nbs or VHHs) are single-domain antibodies (sdAbs) derived from camelid heavy-chain antibodies. Nbs have special and unique characteristics, such as small size, good tissue penetration, and cost-effective production, making Nbs a good ...
Wenyuan Shang, Xiujun Hu, Xiaoman Lin, Shangru Li, Shuchang Xiong, Bingding Huang, Xin Wang   +6 more
doaj   +1 more source

Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc.

PLoS ONE
The activity-regulated cytoskeleton-associated protein (Arc) is a complex regulator of synaptic plasticity in glutamatergic neurons. Understanding its molecular function is key to elucidate the neurobiology of memory and learning, stress regulation, and ...
José M Godoy Muñoz, Lasse Neset, Sigurbjörn Markússon, Sarah Weber, Oda C Krokengen, Aleksi Sutinen, Eleni Christakou, Andrea J Lopez, Clive R Bramham, Petri Kursula   +9 more
doaj   +1 more source

Identification and characterization of nanobodies specifically against African swine fever virus major capsid protein p72

Frontiers in Microbiology, 2022
African swine fever virus (ASFV) is a large and very complex DNA virus. The major capsid protein p72 is the most predominant structural protein and constitutes the outmost icosahedral capsid of the virion.
Jifei Yang, Mengyao Jing, Qingli Niu, Jinming Wang, Yaru Zhao, Yaru Zhao, Meng Liu, Guiquan Guan, Jianxun Luo, Hong Yin, Hong Yin, Zhijie Liu, Zhijie Liu   +12 more
doaj   +1 more source

Epidemiological tools for effective surveillance of porcine cysticercosis in Africa [PDF]

, 2014
peer ...
Farougou, S., Goussanou, J.S.E, Korsak Koulagenko, Nicolas, Kpodekon, M.T., Youssao, A.K.I.   +4 more
core   +11 more sources

Uniform Orientation of Biotinylated Nanobody as an Affinity Binder for Detection of Bacillus thuringiensis (Bt) Cry1Ac Toxin

Toxins, 2014
Nanobodies are the smallest natural fragments with useful properties such as high affinity, distinct paratope and high stability, which make them an ideal tool for detecting target antigens.
Min Li, Min Zhu, Cunzheng Zhang, Xianjin Liu, Yakun Wan   +4 more
doaj   +1 more source

Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function

Frontiers in Endocrinology, 2018
Multi-membrane spanning proteins, such as G protein-coupled receptors (GPCRs) and ion channels, are extremely difficult to purify as native proteins. Consequently, the generation of antibodies that recognize the native conformation can be challenging. By
Xavier Peyrassol, Toon Laeremans, Toon Laeremans, Toon Laeremans, Vannessa Lahura, Maja Debulpaep, Maja Debulpaep, Maja Debulpaep, Hassan El Hassan, Hassan El Hassan, Hassan El Hassan, Jan Steyaert, Jan Steyaert, Marc Parmentier, Marc Parmentier, Ingrid Langer   +15 more
doaj   +1 more source

In planta expression of nanobody-based designer chicken antibodies targeting Campylobacter [PDF]

, 2018
Campylobacteriosis is a widespread infectious disease, leading to a major health and economic burden. Chickens are considered as the most common infection source for humans. Campylobacter mainly multiplies in the mucus layer of their caeca.
De Greve, Henri, Depicker, Anna, Elseviers, Jelle, Garcia Rodriguez, Gabriela, Haesebrouck, Freddy, Hassanzadeh-Ghassabeh, Gholamreza, Hernalsteens, Jean-Pierre, Martel, An, Martens, Edo, Pasmans, Frank, Vanmarsenille, Charlotte, Yvanoff, Charlotte   +11 more
core   +4 more sources

Nanobody Conjugates for Targeted Cancer Therapy and Imaging

Technology in Cancer Research & Treatment, 2021
Conventional antibody-based targeted cancer therapy is one of the most promising avenues of successful cancer treatment, with the potential to reduce toxic side effects to healthy cells surrounding tumor cells.
Wei Kang PhD, Chuanfeng Ding BM, Danni Zheng BS, Xiao Ma BS, Lun Yi BS, Xinyi Tong BS, Chuang Wu MD, Chuang Xue PhD, Yongsheng Yu PhD, Qian Zhou MD   +9 more
doaj   +1 more source

Structure of a bacterial type IV secretion core complex at subnanometre resolution [PDF]

, 2013
Type IV secretion (T4S) systems are able to transport DNAs and/or proteins through the membranes of bacteria. They form large multiprotein complexes consisting of 12 proteins termed VirB1-11 and VirD4.
Chandran, Vidya, Fronzes, Remi, Laeremans, T., Lian, Pei W., Orlova, Elena, Pardon, E., Remaut, Han, Rivera-Calzada, A., Savva, Christos G., Steyaert, J., Waksman, Gabriel   +10 more
core   +1 more source