Results 71 to 80 of about 19,553 (185)

Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury

Journal of Nanobiotechnology, 2023
Background The opening of pannexin1 channels is considered as a key event in inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers inflammasome signaling and activation of immune cells.
Raf Van Campenhout, Timo W. M. De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken   +6 more
doaj   +1 more source

The Therapeutic Potential of Nanobodies [PDF]

BioDrugs, 2019
Today, bio-medical efforts are entering the subcellular level, which is witnessed with the fast-developing fields of nanomedicine, nanodiagnostics and nanotherapy in conjunction with the implementation of nanoparticles for disease prevention, diagnosis, therapy and follow-up.
Ivana Jovčevska, Serge Muyldermans
openaire   +2 more sources

Cortactin and fascin-1 regulate extracellular vesicle release by controlling endosomal trafficking or invadopodia formation and function [PDF]

, 2018
Cancer cell-derived extracellular vesicles (EVs) are increasingly being recognized as genuine invasive structures as they contribute to many aspects of invasion and metastasis.
Beghein, Els, Devriese, Delphine, Gettemans, Jan, Van Hoey, Evy   +3 more
core   +2 more sources

NANOBODIES(®): A Review of Generation, Diagnostics and Therapeutics

, 2023
NANOBODY(®) (a registered trademark of Ablynx N.V) molecules (Nbs), also referred to as single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG antibodies found in the Camelidae family. Due to their small size, simple structure, high antigen binding affinity, and remarkable stability in extreme conditions, nanobodies possess ...
Jin, Bo-Kyung, Odongo, Steven, Radwanska, Magdalena, Stefan, Magez   +3 more
openaire   +2 more sources

Development of multivalent nanobodies blocking SARS-CoV-2 infection by targeting RBD of spike protein

Journal of Nanobiotechnology, 2021
Background The outbreak and pandemic of coronavirus SARS-CoV-2 caused significant threaten to global public health and economic consequences. It is extremely urgent that global people must take actions to develop safe and effective preventions and ...
Qizhong Lu, Zongliang Zhang, Hexian Li, Kunhong Zhong, Qin Zhao, Zeng Wang, Zhiguo Wu, Donghui Yang, Shuang Sun, Nian Yang, Meijun Zheng, Qiang Chen, Cheng Long, Wenhao Guo, Hui Yang, Chunlai Nie, Aiping Tong   +16 more
doaj   +1 more source

Nanobodies—Useful Tools for Allergy Treatment?

Frontiers in Immunology, 2020
In the last decade single domain antibodies (nanobodies, VHH) qualified through their unique characteristics have emerged as accepted and even advantageous alternative to conventional antibodies and have shown great potential as diagnostic and ...
Sabine Flicker, Ines Zettl, Sergei V. Tillib   +2 more
doaj   +1 more source

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models [PDF]

, 2015
Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments.
Azevedo, Vasco, Bermudez Humaran, Luis G., Chatel, Jean Marc, de Moreno, Maria Alejandra, del Carmen, Silvina Andrea, Langella, Philippe, Leblanc, Jean Guy Joseph, Miyoshi, Anderson   +7 more
core   +1 more source

Landau damping in thin films irradiated by a strong laser field

, 2004
The rate of linear collisionless damping (Landau damping) in a classical electron gas confined to a heated ionized thin film is calculated. The general expression for the imaginary part of the dielectric tensor in terms of the parameters of the single ...
D F Zaretsky, Ditmire T, Fomichev S V, Fomichev S V, Fomichev S V, Fomichev S V, Fomichev S V, Fuka M Z, Hache F, Hays G, Kawabata A, Korneev Ph A, Kostyukov I, Kostyukov I Yu, Kreibig U, Landau L D, Landau L D, Landau L D, Lifshitz E M, Megi F, Mero M, Ph A Korneev, S V Popruzhenko, W Becker, Zweiback J   +24 more
core   +1 more source

Anti-IgD nanobodies as novel tools for studying human IgD biology

Scientific Reports
IgD is the least well characterized of mammalian antibody isotypes and its biology remains poorly understood. Nanobodies are a useful and versatile tool for research and diagnostics, including for protein purification, capture and detection applications.
Susan K. Vester, Rebecca L. Beavil, Alexander Alexandrovich, Hannah J. Gould, Andrew J. Beavil, Brian J. Sutton, James M. McDonnell   +6 more
doaj   +1 more source