Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors [PDF]
, 2014 Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme
Böhm, Raphael +14 more
core +1 more source
Lung Xenotransplantation Advances in the Context of Clinical Pandora's Box-Positioned Amid Innovations in Heart, Kidney, and Liver Xenografts. [PDF]
Health Care SciHealth Care Science, Volume 4, Issue 5, Page 317-318, October 2025.
Nashan B.
europepmc +2 more sources
An Overview of the Importance and Value of Porcine Species in Sialic Acid Research
Biology, 2022 Humans frequently interact with pigs, whose meat is also one of the primary sources of animal protein. They are one of the main species at the center of sialic acid (Sia) research.
Oluwamayowa Joshua Ogun +2 more
doaj +1 more source
Systematic Chemoenzymatic Synthesis of O-Sulfated Sialyl Lewis x Antigens. [PDF]
, 2015 O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes.
Chen, Xi +8 more
core +1 more source
Glycosylated Biotherapeutics: Immunological Effects of N-Glycolylneuraminic Acid
Frontiers in Immunology, 2020 The emerging field of biotherapeutics provides successful treatments for various diseases, yet immunogenicity and limited efficacy remain major concerns for many products.
Sharon Yehuda, Vered Padler-Karavani
doaj +1 more source
A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. [PDF]
, 2018 Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to ...
Amon, Ron +12 more
core +2 more sources
Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]
, 2013 The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M +12 more
core +1 more source
Frontiers in Immunology, 2019 Rural lifestyle has been shown to be highly protective against the development of allergies. Contact to farm-animals or pets and early-life consumption of milk products turned out to be important.
Remo Frei +9 more
doaj +1 more source
Mechanisms linking colorectal cancer to the consumption of (processed) red meat : a review [PDF]
, 2015 Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. The vast majority of CRC cases have been linked to environmental causes rather than to heritable genetic changes.
De Smet, Stefaan +3 more
core +2 more sources
PLoS ONE, 2018 BackgroundN-glycolylneuraminic acid (Neu5Gc) is a non-human red-meat-derived sialic acid immunogenic to humans. Neu5Gc can be metabolically incorporated into glycan chains on human endothelial and epithelial surfaces. This represents the first example of
Annie N Samraj +15 more
doaj +1 more source