Results 51 to 60 of about 4,454 (194)
Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates [PDF]
, 2014 Background Pig erythrocytes are potentially useful to solve the worldwide shortage of human blood for transfusion. Domestic pig erythrocytes, however, express antigens that are bound by human preformed antibodies.
Burlak, Christopher +6 more
core +1 more source
BMC Cancer, 2022 Background Normal human tissues do not express glycans terminating with the sialic acid N-glycolylneuraminic acid (Neu5Gc), yet Neu5Gc-containing glycans have been consistently found in human tumor tissues, cells and secretions and have been proposed as ...
Lucy K. Shewell +13 more
doaj +1 more source
Pathogens, 2023 Porcine meat is the most consumed red meat worldwide. Pigs are also vital tools in biological and medical research. However, xenoreactivity between porcine’s N-glycolylneuraminic acid (Neu5Gc) and human anti-Neu5Gc antibodies poses a significant ...
Oluwamayowa Joshua Ogun +2 more
doaj +1 more source
Growth of bifidobacteria in mammalian milk [PDF]
, 2013 Microbial colonization of the mammalian intestine begins at birth, when from a sterile state a newborn infant is exposed to an external environment rich in various bacterial species.
Bunešová, V. +7 more
core +1 more source
Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes [PDF]
, 2015 Background Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens.
Adams, A.B. +9 more
core +1 more source
Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus. [PDF]
, 2017 Sialic acids (Sias) are important glycans displayed on the cells and tissues of many different animals and are frequent targets for binding and modification by pathogens, including influenza viruses.
Ajit Varki +10 more
core +3 more sources
Involvement of a Non-Human Sialic Acid in Human Cancer
Frontiers in Oncology, 2014 Sialic acids are common monosaccharides that are widely expressed as outer terminal units on all vertebrate cell surfaces, and play fundamental roles in cell-cell and cell-microenvironment interactions.
Annie eSamraj +3 more
doaj +1 more source
N-glycolyl chondroitin synthesis using metabolically engineered E. coli
AMB Express, 2020 N-glycolyl chondroitin (Gc-CN) is a metabolite of N -glycolylneuraminic acid (Neu5Gc), a sialic acid that is commonly found in mammals, but not humans. Humans can incorporate exogenous Neu5Gc into their tissues from eating red meat.
Adeola E. Awofiranye +7 more
doaj +1 more source
Gut Microbes, 2021 Gut microbiome composition depends heavily upon diet and has strong ties to human health. Dietary carbohydrates shape the gut microbiome by providing a potent nutrient source for particular microbes.
Joanna K Coker +3 more
doaj +1 more source
Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids
Glycobiology, 2022 Abstract Sialic acids are used as a receptor by several viruses and variations in the linkage type or C-5 modifications affect the binding properties. A species barrier for multiple viruses is present due to α2,3- or α2,6-linked sialic acids.
Nikoloz Nemanichvili +6 more
openaire +3 more sources