Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera. [PDF]
PLoS Pathogens, 2018 While infectious agents have typical host preferences, the noninvasive enteric bacterium Vibrio cholerae is remarkable for its ability to survive in many environments, yet cause diarrheal disease (cholera) only in humans. One key V.
Frederico Alisson-Silva +10 more
doaj +1 more source
Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates. [PDF]
, 2019 Dietary habits have been associated with alterations of the human gut resident microorganisms contributing to obesity, diabetes and cancer1. In Western diets, red meat is a frequently eaten food2, but long-term consumption has been associated with ...
Alisson-Silva, Frederico +14 more
core
Porcine to Human Heart Transplantation: Is Clinical Application Now Appropriate? [PDF]
, 2017 Cardiac xenotransplantation (CXTx) is a promising solution to the chronic shortage of donor hearts. Recent advancements in immune suppression have greatly improved the survival of heterotopic CXTx, now extended beyond 2 years, and life-supporting kidney ...
Byrne, GW, McGregor, CGA
core +1 more source
Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry
PROTEOMICS, EarlyView.ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu +3 more
wiley +1 more source
Challenging the Role of Diet-Induced Anti-Neu5Gc Antibodies in Human Pathologies [PDF]
Frontiers in Immunology, 2020 No abstract ...
Soulillou, Jean-Paul +2 more
openaire +5 more sources
Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus [PDF]
, 2017 Ruminococcus gnavus is a human gut symbiont which ability to degrade mucins is mediated by an intramolecular trans-sialidase (RgNanH). RgNanH comprises a GH33 catalytic domain and a sialic acid binding carbohydrate binding module (CBM40).
Angulo, Jesus +17 more
core +9 more sources
Perinatal Gut Dysbiosis Reduces Milk Oligosaccharides via LPS‐Mediated Gut–Mammary Signaling in Mice
Food Frontiers, Volume 7, Issue 2, March 2026.Maternal gut dysbiosis elevates Gram‐negative bacterial lipopolysaccharide (LPS), which enters circulation and accumulates in mammary tissue. This compromises the blood–milk barrier and suppresses key enzymatic genes, ultimately reducing milk oligosaccharide synthesis and potentially affecting neonatal gut microbiota through breastfeeding.
Man‐Lin Zhou +9 more
wiley +1 more source
N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens [PDF]
, 2015 BACKGROUND: The temporary or long-term xenotransplantation of pig organs into people would save thousands of lives each year if not for the robust human antibody response to pig carbohydrates.
Bern, Marshall +7 more
core +1 more source
mBio, 2019 Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative bacterial pathogen that is adapted exclusively to human hosts. NTHi utilizes sialic acid from the host as a carbon source and as a terminal sugar on the outer membrane glycolipid ...
Preston S. K. Ng +10 more
doaj +1 more source
An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. [PDF]
, 2016 Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated
Chen, Xi +8 more
core +3 more sources