Results 81 to 90 of about 4,454 (194)
Pathogens, 2023 The sugar molecule N-glycolylneuraminic acid (Neu5Gc) is one of the most common sialic acids discovered in mammals. Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) catalyses the conversion of N-acetylneuraminic acid (Neu5Ac) to Neu5Gc ...
Oluwamayowa Joshua Ogun +3 more
doaj +1 more source
Glycosylation of glycolipids in cancer: basis for development of novel therapeutic approaches [PDF]
, 2013 Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the complex ...
Daniotti, Jose Luis +4 more
core +2 more sources
Detection of the dietary xenoglycan N-glycolylneuraminic acid (Neu5Gc) and anti-Neu5Gc antibodies within reproductive tracts of male and female infertility subjects [PDF]
Clinical Obstetrics, Gynecology and Reproductive Medicine, 2015 Objective: To assess the frequency of dietary xenoglycanNeu5Gc and antibodies in males and females and its impact on fertility. Design: Prospective study of semen, uterine lavage, and follicular fluid from subjects undergoing infertility evaluation or in vitro fertilization (IVF) and fertile controls.
Sroga, Julie M. +9 more
openaire +2 more sources
Gene expression and pathway analysis of effects of the CMAH deactivation on mouse lung, kidney and heart. [PDF]
PLoS ONE, 2014 N-glycolylneuraminic acid (Neu5Gc) is generated by hydroxylation of CMP-Neu5Ac to CMP-Neu5Gc, catalyzed by CMP-Neu5Ac hydroxylase (CMAH). However, humans lack this common mammalian cell surface molecule, Neu5Gc, due to inactivation of the CMAH gene ...
Deug-Nam Kwon +2 more
doaj +1 more source
A comparative study of free oligosaccharides in the milk of domestic animals [PDF]
, 2014 This study was conducted to provide a comprehensive analysis of the oligosaccharides in the milk of a variety of important domestic animals including cow, goat, sheep, pig, horse, and dromedary camel.
Al Busadah, Khalid A. +6 more
core +2 more sources
The Nutritional Composition and Multi‐Omics Analysis of Raw Milk From Normande and Holstein Cows
Food Frontiers, Volume 6, Issue 6, Page 3042-3058, November 2025.Normande milk is characterized by high protein and fat content, whereas Holstein milk is distinguished by its high milk yield. However, few studies have reported on their compositional differences. Thus, we used physicochemical and multi‐omics techniques to investigate the compositional differences between Normande and Holstein raw milks. ABSTRACT Milk
Yuanyuan Li +9 more
wiley +1 more source
GM3(Neu5Gc) ganglioside: an evolution fixed neoantigen for cancer immunotherapy
Seminars in Oncology, 2018 Numerous molecules have been considered as targets for cancer immunotherapy because of their levels of expression on tumor cells, their putative importance for tumor biology, and relative immunogenicity. In this review we focus on the ganglioside GM3(Neu5Gc), a glycosphingolipid present on the outer side of the plasma membrane of vertebrate cells.
Mayrel, Labrada +6 more
openaire +2 more sources
MoleculesN-glycolylneuraminic acid (Neu5Gc), a sialic acid predominantly found in the non-neurohumoral fluids of hind-mouthed animals, is incapable of synthesizing Neu5Gc due to a deletion in the CMAH exon of the gene encoding human CMP-Neu5Gc hydroxylase.
Yuxi Guo +11 more
doaj +1 more source
Food Frontiers, Volume 6, Issue 6, Page 3090-3107, November 2025.A high‐fat diet impairs intestinal health by disrupting the mucus layer, widening epithelial gaps, triggering inflammation, and causing microbial dysbiosis, ultimately leading to obesity and metabolic disorders. Sialic acid interventionsparticularly bound forms (3ʹ‐SL and EBN)outperform free Neu5Ac in restoring microbial balance, alleviating ...
Xinyue Wang +10 more
wiley +1 more source
Anti-Neu5Gc Antibody Kit Protocol - ELISA v3 [PDF]
, 2018 This protocol is essentially the same as a standard ELISA protocol, with one major exception - all animal compounds must be avoided in buffers, etc. because they contain Neu5Gc, which will interfere with antibody activity and result in misleading data.
openaire +1 more source