Genetic disorders of neurotransmitter release machinery [PDF]
Frontiers in Synaptic Neuroscience, 2023 Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues.
Burak Uzay +3 more
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Strikingly different neurotransmitter release strategies in dopaminergic subclasses [PDF]
eLifeNeuronal function is intimately tied to axodendritic polarity. Neurotransmitter release, for example, is usually the role of the axon. There are widespread exceptions to this rule, however, including many mammalian neuronal types that can release ...
Ana Dorrego-Rivas +7 more
doaj +3 more sources
Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro [PDF]
Communications Biology, 2023 Microtubules are key to multiple neuronal functions involving the transport of organelles, however, their relationship to neurotransmitter release is still unresolved.
Cecilia D. Velasco +5 more
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Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions [PDF]
Nature CommunicationsIn the pre-synapse, vesicle fusion is a crucial process for neurotransmitter release in the nervous system. Under physiological conditions, synaptotagmin-1 (Syt1) locks synaptic vesicles in a priming state, allowing them to undergo synchronized ...
Yijuan Xiang +13 more
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AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release [PDF]
Frontiers in Molecular Neuroscience, 2023 Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses.
Harrison J. Ramsay +9 more
doaj +2 more sources
The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion [PDF]
Frontiers in Neuroscience, 2023 There are many special sites at the end of a synapse called active zones (AZs). Synaptic vesicles (SVs) fuse with presynaptic membranes at these sites, and this fusion is an important step in neurotransmitter release.
Shanshan Wu +13 more
doaj +2 more sources
Stochastic RNA editing of the Complexin C-terminus within single neurons regulates neurotransmitter release [PDF]
Cell Reports, 2023 Summary: Neurotransmitter release requires assembly of the SNARE complex fusion machinery, with multiple SNARE-binding proteins regulating when and where synaptic vesicle fusion occurs.
Elizabeth A. Brija +3 more
doaj +2 more sources
Molecular Mechanisms Underlying Neurotransmitter Release. [PDF]
Annu Rev Biophys, 2022 Major recent advances and previous data have led to a plausible model of how key proteins mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins syntaxin-1, SNAP-25, and synaptobrevin form tight complexes that bring the membranes together and are crucial ...
Rizo J.
europepmc +3 more sources
Neurotransmitter release progressively desynchronizes in induced human neurons during synapse maturation and aging [PDF]
Cell Reports, 2023 Summary: Rapid release of neurotransmitters in synchrony with action potentials is considered a key hardwired property of synapses. Here, in glutamatergic synapses formed between induced human neurons, we show that action potential-dependent ...
Burak Uzay +5 more
doaj +2 more sources
The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A [PDF]
eLifeThe SNARE proteins are central in membrane fusion and, at the synapse, neurotransmitter release. However, their involvement in the dual regulation of the synchronous release while maintaining a pool of readily releasable vesicles remains unclear. Using a
Andrea Salazar Lázaro +3 more
doaj +2 more sources