LKB1 Regulates Mitochondria-Dependent Presynaptic Calcium Clearance and Neurotransmitter Release Properties at Excitatory Synapses along Cortical Axons. [PDF]
PLoS Biology, 2016 Individual synapses vary significantly in their neurotransmitter release properties, which underlie complex information processing in neural circuits. Presynaptic Ca2+ homeostasis plays a critical role in specifying neurotransmitter release properties ...
Seok-Kyu Kwon +5 more
doaj +1 more source
Dendritic Release of Neurotransmitters [PDF]
Comprehensive Physiology, 2017 ABSTRACTRelease of neuroactive substances by exocytosis from dendrites is surprisingly widespread and is not confined to a particular class of transmitters: it occurs in multiple brain regions, and includes a range of neuropeptides, classical neurotransmitters, and signaling molecules, such as nitric oxide, carbon monoxide, ATP, and arachidonic acid ...
Ludwig, Mike +4 more
openaire +2 more sources
Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. [PDF]
PLoS ONE, 2014 Protein tyrosine kinases, which are highly expressed in the central nervous system, are implicated in many neural processes. However, the relationship between protein tyrosine kinases and neurotransmitter release remains unknown.
Zhao Zhang +9 more
doaj +1 more source
Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens. [PDF]
PLoS ONE, 2011 Prejunctional nicotinic acetylcholine receptors (nAChRs) amplify postganglionic sympathetic neurotransmission, and there are indications that intraterminal Ca(2+) stores might be involved.
Damian J Williams +3 more
doaj +1 more source
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. [PDF]
, 2007 International audienceThe molecular organization of presynaptic active zones is important for the neurotransmitter release that is triggered by depolarization-induced Ca2+ influx.
Beedle, Aaron, +14 more
core +3 more sources
Neurotransmitter release [PDF]
FEBS Letters, 1990 Axon terminals release more than one physiologically active substance. Synaptic messengers may be stored in two different types of vesicles. Small electron‐lucent vesicles mainly store classical low molecular weight transmitter substances and the larger electron‐dense granules store and release proteins and peptides.
openaire +2 more sources
Re-examining how complexin inhibits neurotransmitter release
eLife, 2014 Complexins play activating and inhibitory functions in neurotransmitter release. The complexin accessory helix inhibits release and was proposed to insert into SNARE complexes to prevent their full assembly.
Thorsten Trimbuch +5 more
doaj +1 more source
Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]
, 2016 The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni +5 more
core +1 more source
The role of the C2A domain of synaptotagmin 1 in asynchronous neurotransmitter release.
PLoS ONE, 2020 Following nerve stimulation, there are two distinct phases of Ca2+-dependent neurotransmitter release: a fast, synchronous release phase, and a prolonged, asynchronous release phase.
Mallory C Shields +6 more
doaj +1 more source
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction [PDF]
, 2010 Synaptic dysfunction is widely thought to be a pathogenic precursor to neurodegeneration in Alzheimer’s disease (AD), and the extent of synaptic loss provides the best correlate for the severity of dementia in AD patients.
Ho, Angela +5 more
core +1 more source