Results 1 to 10 of about 628,580 (164)

Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer Models

Frontiers in Immunology, 2021
Although T cell-recruiting CD3-binding bispecific antibodies (BiMAb) have been proven to be clinically effective for hematologic malignancies, the success of BiMAb targeting solid tumor-associated antigens (TAA) in carcinomas so far remains poor.
Karsten M. Warwas, Karsten M. Warwas, Marten Meyer, Marten Meyer, Márcia Gonçalves, Márcia Gonçalves, Gerhard Moldenhauer, Nadja Bulbuc, Susanne Knabe, Claudia Luckner-Minden, Claudia Ziegelmeier, Claus Peter Heussel, Claus Peter Heussel, Claus Peter Heussel, Inka Zörnig, Dirk Jäger, Dirk Jäger, Frank Momburg, Frank Momburg   +18 more
doaj   +1 more source

A new natural killer cell-specific gene signature predicting recurrence in colorectal cancer patients

Frontiers in Immunology, 2023
The protective role of Natural Killer (NK) cell tumour immunosurveillance has long been recognised in colorectal cancer (CRC). However, as most patients show limited intra-tumoral NK cell infiltration, improving our ability to identify those with high NK
Carolyn Shembrey, Carolyn Shembrey, Carolyn Shembrey, Momeneh Foroutan, Momeneh Foroutan, Momeneh Foroutan, Frédéric Hollande, Frédéric Hollande   +7 more
doaj   +1 more source

NK cell education: Physiological and pathological influences

Frontiers in Immunology, 2023
Natural killer (NK) cells represent a critical defense against viral infections and cancers. NK cells require integration of activating and inhibitory NK cell receptors to detect target cells and the balance of these NK cell inputs defines the global NK ...
Philippe Rascle, Philippe Rascle, Griffin Woolley, Griffin Woolley, Stephanie Jost, Stephanie Jost, Cordelia Manickam, Cordelia Manickam, R. Keith Reeves, R. Keith Reeves, R. Keith Reeves   +10 more
doaj   +1 more source

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment

Frontiers in Immunology, 2021
Natural killer (NK) cells are prominent cytotoxic and cytokine-producing components of the innate immune system representing crucial effector cells in cancer immunotherapy.
Natasha Mupeta Kaweme, Fuling Zhou
doaj   +1 more source

Making a Killer: Selecting the Optimal Natural Killer Cells for Improved Immunotherapies

Frontiers in Immunology, 2021
Over the past 20 years natural killer (NK) cell-based immunotherapies have emerged as a safe and effective treatment option for patients with relapsed or refractory leukemia.
Samantha A. Barnes, Samantha A. Barnes, Isabella Trew, Isabella Trew, Emma de Jong, Bree Foley   +5 more
doaj   +1 more source

Prognostic impact of peripheral natural killer cells in primary central nervous system lymphoma

Frontiers in Immunology, 2023
BackgroundPrimary central nervous system lymphoma (PCNSL) is an aggressive extranodal non-Hodgkin lymphoma with a poor prognosis. We aimed to evaluate the prognostic impact of circulating NK cells in PCNSL.Materials and methodsPatients diagnosed with ...
Zhiguang Lin, Jingjing Ma, Yan Ma, Qing Li, Hui Kang, Mengxue Zhang, Bobin Chen, Rong Xia   +7 more
doaj   +1 more source

Identification of Functional Fragments in gMYL6 and the Mechanism of Improving NK Cell-Mediated Cytotoxicity [PDF]

Iranian Journal of Immunology, 2020
Background: In a previous study, the unrecognized role of gMYL6 in the up-regulation of human NK cells development and cytotoxicity was reported. Objective: To further elucidate the mechanism of action of small recombinant fragments of gMYL6 enhancing ...
Yuying Ji, Rui Cao, Guangxin Lv, Yuanyuan Jin, Jing Chen   +4 more
doaj   +1 more source

Comprehensive single-cell transcriptomic and proteomic analysis reveals NK cell exhaustion and unique tumor cell evolutionary trajectory in non-keratinizing nasopharyngeal carcinoma

Journal of Translational Medicine, 2023
Background Nonkeratinizing nasopharyngeal carcinoma (NK-NPC) has a strong association with Epstein-Barr virus (EBV) infection. The role of NK cells and the tumor cell evolutionary trajectory in NK-NPC remain unclear.
Cuimin Chen, Chun Wang, Ruifang Pang, Huanyu Liu, Weihua Yin, Jiakang Chen, Lili Tao   +6 more
doaj   +1 more source

Elbow plank exercise improves immunocyte function and physical fitness in an elderly male: a case study

Journal of Men's Health, 2022
Background: The elbow plank is a common exercise that can easily be done at home, but its effects on physical fitness and immunocyte function in elderly people are unknown.
Ki-Soo Lee, Seung-Jae Heo, Gwang-Seok Hyun, Sang-Kyun Park, Jun-Youl Cha, Yong-Seok Jee   +5 more
doaj   +1 more source

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming [PDF]

, 2018
Natural Killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated.
Angela Santoni, Angela Santoni, Angela Santoni, Chiara Pighi, Cristina Capuano, Gabriella Palmieri, Lavinia Franchitti, Ombretta Turriziani, Ricciarda Galandrini, Simone Battella, Stefania Morrone   +10 more
core   +5 more sources