Human innate immune cell crosstalk induces melanoma cell senescence
OncoImmunology, 2020 Mononuclear phagocytes and NK cells constitute the first line of innate immune defense. How these cells interact and join forces against cancer is incompletely understood.
Felix Funck +10 more
doaj +1 more source
Transgenic expression of the Ly49A natural killer cell receptor confers class I major histocompatibility complex (MHC)-specific inhibition and prevents bone marrow allograft rejection. [PDF]
, 1996 Natural killer (NK) cells and some T cells are endowed with receptors specific for class I major histocompatibility complex (MHC) molecules that can inhibit cellular effector functions.
Cado, D, Held, W, RAULET, David H.
core +1 more source
Frontiers in Immunology, 2015 There is compelling clinical and experimental evidence to suggest natural killer (NK) cells play a critical role in the recognition and eradication of tumors.
Cariad eChester +3 more
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Recent Advances to Augment NK Cell Cancer Immunotherapy Using Nanoparticles
Pharmaceutics, 2021 Among various immunotherapies, natural killer (NK) cell cancer immunotherapy using adoptive transfer of NK cells takes a unique position by targeting tumor cells that evade the host immune surveillance. As the first-line innate effector cell, it has been
Kwang-Soo Kim +2 more
doaj +1 more source
Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. [PDF]
, 2015 We have recently shown that Natural Killer (NK) cells control survival and differentiation of Cancer Stem-like Cells (CSCs) through two distinct phenotypes of cytotoxic and anergic NK cells, respectively. In this report, brain CSCs and their serum and NK
Bui, Vickie T +6 more
core +1 more source
Alteration in blood leukocyte profile due to exercise and its implication
Journal of Physical Fitness and Sports Medicine, 2013 Evaluation of peripheral blood leukocytes has been considered a popular window to the immune system and its response. The numeration of leukocytes has long been a practical clinical marker of acute inflammation.
Ryoichi Nagatomi
doaj +1 more source
A novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activity
OncoImmunology, 2022 A major challenge in natural killer (NK) cell immunotherapy is the limited persistence of NK cells in vivo. However, the proliferation of NK cells is dependent on cytokines such as interleukin-2 (IL-2).
Qi Xiong +14 more
doaj +1 more source
Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]
, 2015 Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni +67 more
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Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]
, 2012 Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Burghard F. Klapp +11 more
core +11 more sources
Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. [PDF]
, 2019 Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies.
Ames, Erik +8 more
core +1 more source