Results 111 to 120 of about 21,899 (194)

Type I IFN-mediated regulation of IL-1 production in inflammatory disorders [PDF]

, 2018
Although contributing to inflammatory responses and to the development of certain autoimmune pathologies, type I interferons (IFNs) are used for the treatment of viral, malignant, and even inflammatory diseases.
Du Pasquier, Renaud, Guarda, Greta, Ludigs, Kristina, Parfenov, Valeriy   +3 more
core  

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

Frontiers in Cell and Developmental Biology
High mobility group box-1 (HMGB1) is a protein released from stressed or damaged cells that triggers immune activation and chronic inflammation.
Lei Yang, Xue Li, Xiaoming Zhu, Futao Ge, Yuantao Wang   +4 more
doaj   +1 more source

RBPMS2 can inhibit the NLRP3 / caspase-1 / GSDMD signaling pathway to resist pyroptosis in gastric cancer cells

Scientific Reports
Gastric cancer (GC) is one of the most common malignancies worldwide, and its development is closely associated with the abnormal expression of numerous genes. RNA - binding protein with multiple splicing 2 (RBPMS2), a member of the RNA - binding protein
Nailin Zhang, Lina Yan, Hua Cao, Nana Zhang, Tong Zhang, Shengjiang Guan, Qiquan Liu   +6 more
doaj   +1 more source

The effect of cortex eucommiae on alleviating lung injury induced by Haemophilus paragallinarum

Poultry Science
To analyze whether Cortex Eucommiae (CE) can inhibit pathological lung injury by regulating autophagy levels in chicks lung tissue and identify potential targets, thereby alleviating pneumonia damage caused by Haemophilus paragallinarum (Hp) infection ...
Bo Zhang, Bo Liao, Rou Sang, Rong Liao, Dengyao Xu, Yanhong Lv, Fangjie Li, Ke Li, Aiguo Xin   +8 more
doaj   +1 more source

Tmem30a protects against podocyte injury through suppression of pyroptosis

iScience
Summary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou, Sipei Chen, Lei Peng, Liming Huang, Huijian Zhang, Ping Zhang, Min Yu, Lin Xiong, Xiang Zhong, Wenjing Liu, Xianjun Zhu, Li Wang, Yi Li, Guisen Li   +13 more
doaj   +1 more source

Inter-relationships of galectin-3 and NLR family pyrin domain containing 3 inflammasomes with oral lichen planus: a preliminary cross-sectional in vitro study

BMC Oral Health
Background The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome has been reported to be highly expressed in oral lesions with the potential for malignant development such as oral ...
Siting Chen, Xiaoheng Xu, Yang Liu, Yanmei Yao, Yinshen Yang, Wenxia Meng   +5 more
doaj   +1 more source

NLRP3 activation induces BBB disruption and neutrophil infiltration via CXCR2 signaling in the mouse brain

Journal of Neuroinflammation
NLRP3 is an intracellular sensor molecule that affects neutrophil functionality and infiltration in brain disorders such as experimental autoimmune encephalomyelitis (EAE).
Jaeho Lee, Wooyoung Cho, Je-Wook Yu, Young-Min Hyun   +3 more
doaj   +1 more source

PRRSV NSP5 orchestrates dual immune disruption by targeting NLRP3 and STING

Veterinary Research
Inflammasomes and interferons are two critical defense mechanisms of innate immunity, and their imbalance is a key strategy employed by viruses to evade host immune surveillance.
Xiangyu Huang, Xuyan Xiang, Xiaohan Jiang, Weiyu Qu, Yufei Zhang, Zhenchao Zhao, Minjie Li, Haiwei Wang, Xin Li   +8 more
doaj   +1 more source

miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation. [PDF]

Arch Rheumatol
Yuan X, Lin C, Zhang Y, He H, Li L.
europepmc   +1 more source

Predictive Value of Pyroptosis Markers (NLRP3, HMGB1, and Caspase-1) in the Prognosis of Patients With Metastatic Breast Cancer: A Prospective Observational Study. [PDF]

Breast J
Zhang Y, He Y, Liu Q, Deng H.
europepmc   +1 more source