Results 1 to 10 of about 106,369 (300)
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Nature, 2010 The inflammatory nature of atherosclerosis is well established but the agent(s) that incite inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible to atherosclerosis, suggesting that endogenous substances initiate the ...
Peter Duewell +17 more
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Zhike Erfang Alleviates MRSA-Induced Pneumonia by Inhibiting TRAF6 and Activating NLRP3 Inflammatory Body [PDF]
Journal of Inflammation ResearchLian-Qing Zhang,1,* Wen-Can Zheng,2 Wen-Yan Li3,* 1Department of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China; 2Department of Pharmacy, First People’s Hospital of Qujing City ...
Zhang LQ, Zheng WC, Li WY
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UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
Journal of Clinical Investigation, 2023 . Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory responses remain unclear. The NLRP3 inflammasome serves as a platform for caspase-1–dependent
Jong-Seok Moon +11 more
semanticscholar +1 more source
The anti-inflammatory regulation of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis [PDF]
International Journal of Ophthalmology, 2020 AIM: To analyze the impact of calcitonin gene-related peptide (CGRP) in mouse keratitis after Aspergillus fumigatus (A. fumigatus) infection. METHODS: C57BL/6 mice were treated subconjunctivally with different concentrations of exogenous CGRP, and BALB ...
Ming Xu +7 more
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NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design [PDF]
International Journal of Biological Macromolecules 246 (2023)
125609, 2023 The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the symptoms of pathologic neuroinflammation.
arxiv +1 more source
The NLRP3 inflammasome: contributions to inflammation-related diseases
Cellular & Molecular Biology Letters, 2023 The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18.
Ying Chen +11 more
semanticscholar +1 more source
Pharmacological Reviews, 2023 The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and effector functions to regulate inflammation in health and disease.
Qiang Ma
semanticscholar +1 more source
The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
Frontiers in Immunology, 2023 NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Xiaoyan Zhan +4 more
semanticscholar +1 more source
Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation.
Annual Review of Immunology, 2022 As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic invasions and endogenous cellular damage and responds by forming the NLRP3 inflammasome, a supramolecular complex that activates caspase-1.
Jianing Fu, Hao Wu
semanticscholar +1 more source
Frontiers in Aging Neuroscience, 2022 The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating the innate immune system and inflammatory signaling. Upon activation by PAMPs and DAMPs, NLRP3 oligomerizes and activates caspase-1 which initiates the processing ...
Hallie Blevins +3 more
semanticscholar +1 more source