Results 1 to 10 of about 150,409 (337)
Erratum to "Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization". [PDF]
Research (Wash D C)Lv H +7 more
europepmc +2 more sources
NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation [PDF]
International Journal of Molecular Sciences, 2021 In response to diverse pathogenic and danger signals, the cytosolic activation of the NLRP3 (NOD-, LRR-, and pyrin domain-containing (3)) inflammasome complex is a critical event in the maturation and release of some inflammatory cytokines in the state of an inflammatory response.
Mahbuba Akther +4 more
openaire +2 more sources
Inhibiting the NLRP3 Inflammasome [PDF]
Molecules, 2020 Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome.
Lina Y. El-Sharkawy +2 more
openaire +5 more sources
S-Nitrosoglutathione protects acute kidney injury in septic rats by inhibiting the activation of NLRP3 inflammasome [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): We aimed to study the effect of S-nitroso glutathione (SNG) on acute kidney injury (AKI) in septic rats by regulating nucleotide oligomerization domain-like receptor protein 3 (NLRP3).Materials and Methods: Sprague Dawley rats were used to ...
Heng Fan +3 more
doaj +1 more source
Journal of Clinical Immunology, 2019 Cryopyrin-associated periodic syndrome (CAPS) is a rare inherited autoinflammatory disorder characterized by systemic, cutaneous, musculoskeletal, and central nervous system inflammation. Gain-of-function mutations in NLRP3 in CAPS patients lead to activation of the cryopyrin inflammasome, resulting in the inappropriate release of inflammatory ...
Laela M. Booshehri, Hal M. Hoffman
openaire +2 more sources
Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To explore the effects and mechanism of three types of fresh Rehmannia glutinosa, namely Beijing No. 3 (BJ3H), Huaizhong No. 1 (HZ1H), and Taisheng (TS) on lipopolysaccharide (LPS)-induced acute kidney injury in the sepsis (S-AKI) mice ...
Meng Liu +11 more
doaj +1 more source
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5 [PDF]
The Journal of Immunology, 2020 Abstract The cytosolic pattern recognition receptor NLRP3 senses host-derived danger signals and certain microbe-derived products in both humans and rodents. NLRP3 activation assembles an inflammasome complex that contains the adapter proteins ASC and caspase-1, whose activation triggers the maturation and release of the proinflammatory ...
Wei Zhao +6 more
openaire +2 more sources
Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells
Cells, 2020 Schizophrenia is a complex psychiatric disorder that exhibits an interconnection between the immune system and the brain. Experimental and clinical studies have suggested the presence of neuroinflammation in schizophrenia.
Vijayasree V. Giridharan +9 more
doaj +1 more source
Lyssavirus Matrix Protein Inhibits NLRP3 Inflammasome Assembly by Binding to NLRP3
Cell Reports, 2023 Lyssavirus is a kind of neurotropic pathogen that needs to evade peripheral host immunity to enter the central nervous system to accomplish infection. NLRP3 inflammasome activation is essential for the host to defend against pathogen invasion. This study demonstrates that the matrix protein (M) of lyssavirus can inhibit both the priming step and the ...
Baokun Sui +10 more
openaire +3 more sources
Archives of Pharmaceutical Sciences Ain Shams University, 2023 Background: Breast cancer (BC) is considered the main cause of death in women worldwide. Overexpression of Sphingosine 1-phosphate (S1P) receptors in estrogen receptor (ER) negative BC patients is linked to poor prognosis.
Anas R. Soltan +3 more
doaj +1 more source