Nuclear envelope remnants: fluid membranes enriched in sterols and polyphosphoinositides.
PLoS ONE, 2009 BackgroundThe cytoplasm of eukaryotic cells is a highly dynamic compartment where membranes readily undergo fission and fusion to reorganize the cytoplasmic architecture, and to import, export and transport various cargos within the cell.
Marie Garnier-Lhomme +7 more
doaj +1 more source
Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling
Cells, 2019 The primary functions of the nuclear envelope are to isolate the nucleoplasm and its contents from the cytoplasm as well as maintain the spatial and structural integrity of the nucleus.
Miki Hieda
doaj +1 more source
Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications. [PDF]
PLoS ONE, 2015 The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation development. Up to the onset of major embryonic genome activation (MGA) at the 8-cell stage nuclei showed a non-uniform ...
Jens Popken +9 more
doaj +1 more source
Nuclear Envelope Regulation of Oncogenic Processes: Roles in Pancreatic Cancer
Epigenomes, 2018 Pancreatic cancer is an aggressive and intractable malignancy with high mortality. This is due in part to a high resistance to chemotherapeutics and radiation treatment conferred by diverse regulatory mechanisms.
Claudia C. Preston +1 more
doaj +1 more source
Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms
Epigenetics & Chromatin, 2022 The cause of nuclear shape abnormalities which are often seen in pre-neoplastic and malignant tissues is not clear. In this study we report that deformation of the nucleus can be induced by TGFβ1 stimulation in several cell lines including Huh7.
Ya-Hui Chi +5 more
doaj +1 more source
The Arabidopsis Nuclear Pore and Nuclear Envelope [PDF]
The Arabidopsis Book, 2010 The nuclear envelope is a double membrane structure that separates the eukaryotic cytoplasm from the nucleoplasm. The nuclear pores embedded in the nuclear envelope are the sole gateways for macromolecular trafficking in and out of the nucleus. The nuclear pore complexes assembled at the nuclear pores are large protein conglomerates composed of ...
Iris, Meier, Jelena, Brkljacic
openaire +2 more sources
Nuclear Envelope Permeability Barrier as a Fast‐Response Intracellular Mechanostat
Advanced Science, 2019 The nuclear envelope is an undisputed component of the intracellular mechanotransduction cascades which collect, process, and respond to mechanical stimuli from the environment.
Victor Shahin +3 more
doaj +1 more source
Nuclear envelope mechanobiology: linking the nuclear structure and function
Nucleus, 2021 The nucleus, central to cellular activity, relies on both direct mechanical input as well as its molecular transducers to sense external stimuli and respond by regulating intra-nuclear chromatin organization that determines cell function and fate.
Matthew Goelzer +4 more
doaj +1 more source
Dynamics and Structure-Function Relationships of the Lamin B Receptor (LBR). [PDF]
PLoS ONE, 2017 The lamin B receptor (LBR) is a multi-spanning membrane protein of the inner nuclear membrane that is often employed as a "reporter" of nuclear envelope dynamics. We show here that the diffusional mobility of full-length LBR exhibits significant regional
Ioannis Giannios +2 more
doaj +1 more source
Microorganisms, 2021 The malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within an intact nuclear envelope, and differs significantly from its human host. Mitosis is underpinned by the dynamics of microtubules and the nuclear envelope.
Benjamin Liffner, Sabrina Absalon
doaj +1 more source