Molecular profiling of nucleocytoplasmic transport factor genes in breast cancer [PDF]
Heliyon, 2021 Transport of functional molecules across the nuclear membrane of a eukaryotic cell is regulated by a dedicated set of transporter proteins that carry molecules into the nucleus or out of the nucleus to the cytoplasm for homeostasis of the cell.
Rashid Mehmood +3 more
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Coupling of Perinuclear Actin Cap and Nuclear Mechanics in Regulating Flow‐Induced Yap Spatiotemporal Nucleocytoplasmic Transport [PDF]
Advanced Science, 2023 Mechanical forces, including flow shear stress, govern fundamental cellular processes by modulating nucleocytoplasmic transport of transcription factors like Yes‐associated Protein (YAP). However, the underlying mechanical mechanism remains elusive.
Tianxiang Ma +22 more
doaj +3 more sources
The bioenergetics of nucleocytoplasmic transport. [PDF]
J Cell BiolHow nucleocytoplasmic transport (NCT) rates change due to cellular physiology-mediated fluctuations in GTP availability remains unclear. In this issue, Scott et al. (https://doi.org/10.1083/jcb.202308152) demonstrate that cell migration, spreading, and nucleocytoskeletal coupling impact GTP levels, thereby regulating NCT, RNA export, and protein ...
Luxton GWG.
europepmc +5 more sources
Exportin-mediated nucleocytoplasmic transport maintains Pch2 homeostasis during meiosis. [PDF]
PLoS Genetics, 2023 The meiotic recombination checkpoint reinforces the order of events during meiotic prophase I, ensuring the accurate distribution of chromosomes to the gametes.
Esther Herruzo +5 more
doaj +2 more sources
Mechanosensitivity of nucleocytoplasmic transport [PDF]
, 2021 AbstractMechanical force controls fundamental cellular processes in health and disease, and increasing evidence shows that the nucleus both experiences and senses applied forces. Here we show that nuclear forces differentially control passive and facilitated nucleocytoplasmic transport, setting the rules for the mechanosensitivity of shuttling proteins.
Ion Andreu +9 more
openaire +2 more sources
Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex. [PDF]
PLoS Biology, 2016 The nuclear pore complex (NPC) is responsible for nucleocytoplasmic transport and constitutes a hub for control of gene expression. The components of NPCs from several eukaryotic lineages have been determined, but only the yeast and vertebrate NPCs have ...
Samson O Obado +7 more
doaj +8 more sources
Nuclear pore complex and nucleocytoplasmic transport disruption in neurodegeneration. [PDF]
FEBS Lett, 2023 Nuclear pore complexes (NPCs) play a critical role in maintaining the equilibrium between the nucleus and cytoplasm, enabling bidirectional transport across the nuclear envelope, and are essential for proper nuclear organization and gene regulation ...
Cristi AC, Rapuri S, Coyne AN.
europepmc +2 more sources
Traffic jam at the nuclear pore: All roads lead to nucleocytoplasmic transport defects in ALS/FTD
Neurobiology of Disease, 2020 Amyotrophic lateral sclerosis (ALS) is a fatal late-onset neurodegenerative disease that specifically affects the function and survival of spinal and cortical motor neurons.
Claudia Fallini +3 more
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Mechanical force application to the nucleus regulates nucleocytoplasmic transport. [PDF]
Nat Cell Biol, 2022 Mechanical force controls fundamental cellular processes in health and disease, and increasing evidence shows that the nucleus both experiences and senses applied forces.
Andreu I +11 more
europepmc +2 more sources
Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport. [PDF]
Nat Commun, 2022 The emergence of heavily mutated SARS-CoV-2 variants of concern (VOCs) place the international community on high alert. In addition to numerous mutations that map in the spike protein of VOCs, expression of the viral accessory proteins ORF6 and ORF9b ...
Gao X +8 more
europepmc +2 more sources