Results 21 to 30 of about 2,216,606 (233)
Frontiers in Genetics, 2019 Glioma is a common malignancy with poor prognosis. Recent evidence suggests that the pathogenesis and progression of glioma involve long noncoding RNAs (lncRNAs).
Rong Zheng +5 more
doaj +2 more sources
RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. [PDF]
FASEB J, 2022 Arginine–serine (RS) domain(s) in splicing factors are critical for protein–protein interaction in pre‐mRNA splicing. Phosphorylation of RS domain is important for splicing control and nucleocytoplasmic transport in the cell. RNA‐binding motif 20 (RBM20)
Zhang Y +11 more
europepmc +2 more sources
The Role of Nucleocytoplasmic Transport Defects in Amyotrophic Lateral Sclerosis. [PDF]
Int J Mol Sci, 2021 There is ample evidence that nucleocytoplasmic-transport deficits could play an important role in the pathology of amyotrophic lateral sclerosis (ALS).
Vanneste J, Van Den Bosch L.
europepmc +2 more sources
Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration. [PDF]
Int J Mol Sci, 2021 Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis. Accumulating evidence has demonstrated that dysregulations of NCT are implicated
Ding B, Sepehrimanesh M.
europepmc +2 more sources
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. [PDF]
Nat Neurosci, 2021 Lin YC +17 more
europepmc +2 more sources
Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology. [PDF]
Elife, 2021 Traumatic brain injury (TBI) is a predisposing factor for many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and chronic traumatic encephalopathy (CTE).
Anderson EN +14 more
europepmc +2 more sources
Eukaryotic Ribosome assembly and Nucleocytoplasmic Transport.
Methods Mol Biol, 2022 The process of eukaryotic ribosome assembly stretches across the nucleolus, the nucleoplasm and the cytoplasm, and therefore relies on efficient nucleocytoplasmic transport. In yeast, the import machinery delivers ~140,000 ribosomal proteins every minute
Oborská-Oplová M +3 more
europepmc +2 more sources
Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington's Disease PSC-Derived Striatal Neurons. [PDF]
Front Cell Neurosci, 2021 Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT). Disease progression is characterized by the loss of vulnerable neuronal populations within the striatum.
Lange J +11 more
europepmc +2 more sources
mBio, 2021 SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19), is an RNA virus with a large genome that encodes multiple accessory proteins.
A. Addetia +11 more
semanticscholar +1 more source
Nucleocytoplasmic Transport [PDF]
Science, 1996 Active transport of proteins and RNAs between the nucleus and cytoplasm is a major process in eukaryotic cells. Recently, factors that recognize transport substrates and mediate nuclear import or export have been characterized, revealing interactions that target substrates to the nuclear pore complexes, through which translocation occurs. Translocation
Görlich, D., Mattaj, I.
openaire +3 more sources