Results 31 to 40 of about 2,216,606 (233)

Nucleocytoplasmic transport at the crossroads of proteostasis, neurodegeneration and neuroprotection

FEBS Letters, 2023
Nucleocytoplasmic transport comprises the multistep assembly, transport, and disassembly of protein and RNA cargoes entering and exiting nuclear pores.
P. Ferreira
semanticscholar   +1 more source

Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. [PDF]

Cell Rep, 2022
Nataraj NB, Noronha A, Lee JS, Ghosh S, Mohan Raju HR, Sekar A, Zuckerman B, Lindzen M, Tarcitano E, Srivastava S, Selitrennik M, Livneh I, Drago-Garcia D, Rueda O, Caldas C, Lev S, Geiger T, Ciechanover A, Ulitsky I, Seger R, Ruppin E, Yarden Y.   +21 more
europepmc   +2 more sources

How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System

Cells, 2021
The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response.
Elma Sakinatus Sajidah, Keesiang Lim, Richard W. Wong   +2 more
doaj   +1 more source

Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity

Frontiers in Bioengineering and Biotechnology, 2022
Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes.
Zahra Safaei, Gary L. Thompson
doaj   +1 more source

Reversibility in nucleocytoplasmic transport [PDF]

Proceedings of the National Academy of Sciences, 2007
Nucleocytoplasmic exchange of proteins and RNAs is mediated by receptors that usher their cargo through the nuclear pores. Peptide localization signals on each cargo determine the receptors with which it will interact. Those interactions are normally regulated by the small GTPase Ran.
Ronen Benjamine, Kopito, Michael, Elbaum
openaire   +2 more sources

On the asymmetric partitioning of nucleocytoplasmic transport - recent insights and open questions.

Journal of Cell Science, 2021
Macromolecular cargoes are asymmetrically partitioned in the nucleus or cytoplasm by nucleocytoplasmic transport (NCT). At the center of this activity lies the nuclear pore complex (NPC), through which soluble factors circulate to orchestrate NCT.
Joanna Kalita, L. Kapinos, Roderick Y. H. Lim   +2 more
semanticscholar   +1 more source

SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome

Orphanet Journal of Rare Diseases, 2023
Background Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement.
Giacomo Bitetto, Gianluca Lopez, Dario Ronchi, Alessandra Pittaro, Valentina Melzi, Erika Peverelli, Fulvia Milena Cribiù, Giacomo P. Comi, Giovanna Mantovani, Alessio Di Fonzo   +9 more
doaj   +1 more source

Functional networks of nucleocytoplasmic transport-related genes differentiate ischemic and dilated cardiomyopathies. A new therapeutic opportunity. [PDF]

PLoS ONE, 2014
Heart failure provokes alterations in the expression of nucleocytoplasmic transport-related genes. To elucidate the nucleocytoplasmic transport-linked functional network underlying the two major causes of heart failure, ischemic cardiomyopathy (ICM) and ...
María Micaela Molina-Navarro, Juan Carlos Triviño, Luis Martínez-Dolz, Francisca Lago, Jose Ramón González-Juanatey, Manuel Portolés, Miguel Rivera   +6 more
doaj   +1 more source

Functional insights of nucleocytoplasmic transport in plants

Frontiers in Plant Science, 2014
Plant nucleocytoplasmic transport beyond the nuclear envelope is important not only for basic cellular functions but also for growth, development, hormonal signalling, and responses to environmental stimuli.
Kentaro eTamura, Ikuko eHara-Nishimura
doaj   +1 more source

Role of Nucleoporins and Transport Receptors in Cell Differentiation

Frontiers in Physiology, 2020
Bidirectional molecular movements between the nucleus and cytoplasm take place through nuclear pore complexes (NPCs) embedded in the nuclear membrane.
Asmat Ullah Khan, Rongmei Qu, Jun Ouyang, Jingxing Dai   +3 more
doaj   +1 more source