Results 181 to 190 of about 39,916 (217)

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source

<i>Schisandra chinensis</i> alleviates dextran sulfate sodium-induced colitis in association with remodeling of a <i>Parabacteroides goldsteinii</i>-related leucine-isovalerate metabolic axis and attenuation of mTOR/HIF-1α/IL-17 signaling. [PDF]

Front Microbiol
Song J, Kan H, Jin H, Yue L, Qian Z, Wang B, Xia Z, Zhou Y, Zhang J.   +8 more
europepmc   +1 more source

Oral Butyrate Reduces Progression of Kidney Damage in an L‐NAME‐Induced Diabetic Kidney Disease Mouse Model

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic kidney disease (DKD) is one of the main causes of kidney failure worldwide. Interestingly, patients affected by DKD are characterised by a low abundance of gut bacteria producing short fatty acids including butyrate, which is suggested to play a role in the decline of renal function.
Maria Novella Nicese, Angela Koudijs, Reshma Lalai, Cristina Avramut, Rico J. E. Derks, Elena Sánchez‐López, Martin Giera, Amanda C. M. Pronk, Artemiy Kovynev, Sander Kooijman, Patrick C. N. Rensen, Roel Bijkerk, Bernard M. van den Berg, Joris I. Rotmans   +13 more
wiley   +1 more source

Mechanisms of Polystyrene Microplastics in Multipathway Disruption of the Blood-Testis Barrier. [PDF]

Andrology
Liu H, Adili A, Tian H, Han X.
europepmc   +1 more source

Effects of GLP‐1 agonists on the gut microbiota in type 2 diabetes mellitus: a systematic review

The FEBS Journal, EarlyView.
This systematic review evaluated 17 studies (12 preclinical and five clinical) on GLP‐1 receptor agonists in type 2 diabetes, demonstrating effects on the gut microbiota and metabolic improvement. The studies showed an increase in Bacteroidetes, Lactobacillus, and Akkermansia, and a reduction in Firmicutes.
Ranicleide Santos Dantas, Lucas Vinícius Souza Santos, André Gustavo Carvalho de Oliveira, Marina dos Santos Barreto, Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Eloia Emanuelly Dias Silva, Ronaldy Santana Santos, Lucas Alves da Mota Santana, Rajiv Gandhi Gopalsamy, Adriana Gibara Guimarães, Lysandro Pinto Borges   +11 more
wiley   +1 more source

Dietary betaine alleviates corticosterone-induced intestinal barrier dysfunction in laying hens possibly by promoting tight junction protein expression via m⁶A methylation-mediated inhibition of the NF-κB pathway. [PDF]

Poult Sci
Wu Y, Meng F, Yang Y, Cao C, Hu Y, Ling X, Zhang L, Cui X, Li T, Wang S, Luo X, Hu Y.   +11 more
europepmc   +1 more source

Trans‐resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis

International Journal of Cosmetic Science, EarlyView.
In a cytokine‐challenged human epidermal model, trans‐resveratrol reduces inflammation (IL‐1α) and oxidative stress markers (CYP1A1, CYP1B1), while modulating the expression of barrier‐related genes (LOR, OCLN) and differentiation‐associated CASP14. This supports its role as a multifunctional active for sensitive and compromised skin.
Irini M. Dijkhoff, Sandeep Keshavan, Regina G. Daré, Alke Petri‐Fink, Marc Eeman, Agnès Tessier, Barbara Rothen‐Rutishauser   +6 more
wiley   +1 more source

HAMSIAA protects cyclophosphamide induced immunosuppression by modulating gut homeostasis and purine metabolism. [PDF]

Front Immunol
Zhang D, Song Y, Guo S, Cui X, Dong H, Li Q, Wang Q, Mackay CR, Qu X.   +8 more
europepmc   +1 more source

Endodontic Treatment of Apical Periodontitis Mitigates Systemic Inflammation and Restores the Blood–Brain Barrier Integrity in an In Vitro Model

International Endodontic Journal, EarlyView.
ABSTRACT Aim A growing body of research supports an association between periapical inflammation and an increased risk of various systemic effects. However, there is currently no scientific evidence demonstrating a causal relationship between this inflammation and changes in epithelial or endothelial permeability in patients with apical periodontitis ...
Loredana Bergandi, Mario Alovisi, Elena Tachis, Nicola Scotti, Andrea Baldi, Iris Chiara Salaroglio, Sabrina Digiovanni, Lorena Charrier, Francesca Silvagno, Damiano Pasqualini   +9 more
wiley   +1 more source

Effects of Dietary Wild Thyme Alone or Combined with Probiotic or Prebiotic Supplementation on Growth Performance, Immune Response, Oxidative Status, and Intestinal Health in Broiler Chickens. [PDF]

Vet Sci
Aboragah AA, Alharthi AS, Al-Baadani HH.
europepmc   +1 more source