Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
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Taohe Chengqi Decoction Attenuates Cognitive Impairment in Experimental Sepsis-Associated Encephalopathy. [PDF]
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