Results 101 to 110 of about 22,170 (231)

Reply: Sensorineural hearing loss in OPA1-linked disorders [PDF]

Brain, 2013
ARTICLE Sir, Autosomal dominant optic atrophy (DOA) is the most common inherited optic neuropathy seen in clinical practice, and in >60% of cases, the underlying genetic defect is a pathogenic mutation within the OPA1 gene (Ferre et al. , 2009; Yu-Wai-Man et al. , 2010 a ). The pathological hallmark of this disorder is the preferential loss of retinal
Yu-Wai-Man, Patrick, Chinnery, Patrick F.   +1 more
openaire   +2 more sources

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. [PDF]

, 2016
BackgroundHIV-associated neurocognitive disorders (HAND) continue to be a common morbidity associated with chronic HIV infection. It has been shown that HIV proteins (e.g., gp120) released from infected microglial/macrophage cells can cause neuronal ...
Achim, Cristian, Adame, Anthony, Desplats, Paula, Fields, Jerel A, Florio, Jazmin, Mante, Michael, Masliah, Eliezer, Overk, Cassia, Pineda, Andrea, Rockenstein, Edward   +9 more
core   +1 more source

The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases

Exploration, EarlyView.
This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang   +3 more
wiley   +1 more source

Protective Effect of Aerobic Training along with Resveratrol on Mitochondrial Dynamics of Cardiac Myocytes in Animal Model of Non-alcoholic Fatty Liver Disease

Journal of Ardabil University of Medical Sciences, 2019
Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction. The aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of OPA1 and DRP1 in ...
hasan delroz, Ahmad Abdi, Alireza Barari, Parvin Farzanegi   +3 more
doaj  

OPA1 functions in mitochondria and dysfunctions in optic nerve [PDF]

, 2009
OPA1 is the major gene responsible for Dominant Optic Atrophy (DOA), a blinding disease that affects specifically the retinal ganglion cells (RGCs), which function consists in connecting the neuro-retina to the brain.
A. Olichon, B. Ducommun, C. Delettre, C. Hamel, C. Soukkarieh, G. El Achouri, G. Lenaers, L. Baricault, P. Belenguer, P. Reynier   +9 more
core   +3 more sources

HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation [PDF]

, 2020
Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Allen, George F. G., Ganley, Ian G., Rodger, Catherine E., Weidlich, Simone, Zhao, Jin-Feng   +4 more
core   +3 more sources

Mitochondrial dysfunction in an Opa1Q285STOP mouse model of dominant optic atrophy results from Opa1 haploinsufficiency [PDF]

Cell Death & Disease, 2016
AbstractMutations in the opa1 (optic atrophy 1) gene lead to autosomal dominant optic atrophy (ADOA), a hereditary eye disease. This gene encodes the Opa1 protein, a mitochondrial dynamin-related GTPase required for mitochondrial fusion and the maintenance of normal crista structure. The majority of opa1 mutations encode truncated forms of the protein,
Kushnareva, Y., Seong, Y., Andreyev, A. Y., Kuwana, T., Kiosses, W. B., Votruba, M., Newmeyer, D. D.   +6 more
openaire   +2 more sources

Joint measurement of multiple noncommuting parameters [PDF]

, 2018
Although quantum metrology allows us to make precision measurements beyond the standard quantum limit, it mostly works on the measurement of only one observable due to the Heisenberg uncertainty relation on the measurement precision of noncommuting ...
Assad, Syed M., Cui, Liang, Huo, Nan, Li, Jiamin, Li, Xiaoying, Liu, Yuhong, Ou, Z. Y.   +6 more
core   +3 more sources

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion [PDF]

Cell, 2006
Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the organelle and remodeling of the cristae. Here we provide evidence that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy ...
Frezza, Christian, Cipolat, Sara, de Brito, Olga Martins, Micaroni, Massimo, Beznoussenko, Galina V., Rudka, Tomasz, Bartoli, Davide, Polishuck, Roman S., Danial, Nika N., De Strooper, Bart, Scorrano, Luca   +10 more
openaire   +5 more sources