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Orexins in apoptosis: a dual regulatory role [PDF]
Frontiers in Cellular NeuroscienceThe orexins, also referred to as hypocretins, are neuropeptides that originate from the lateral hypothalamus (LH) region of the brain. They are composed of two small peptides, orexin-A, and orexin-B, which are broadly distributed throughout the central ...
Simona Cavalu +8 more
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The Orexin/Hypocretin System, the Peptidergic Regulator of Vigilance, Orchestrates Adaptation to Stress [PDF]
BiomedicinesThe orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful
Miklós Jászberényi +4 more
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Hypothalamic orexins as possible therapeutic agents in threat and spatial memory disorders [PDF]
Frontiers in Behavioral Neuroscience, 2023 Orexin-A and orexin-B, neuropeptides produced exclusively in the lateral hypothalamus, have been implicated in various functions, including memory. Their levels are elevated in certain pathological states, such as PTSD, and lowered in other states, e.g.,
Filip Mazur, Jarosław Całka
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The Orexin receptors: Structural and anti-tumoral properties
Frontiers in Endocrinology, 2022 At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were discovered.
Alain Couvineau +3 more
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Orexins and bipolar disorder: A review
European Psychiatry, 2022 Introduction Bipolar disorder (BD) is a chronic deteriorating illness which has a strong impact on functionality. In the past few years, orexins have gained importance as possible biomarkers of circadian rhythms, affected in BD. Up to this date, we have
C. Moya Lacasa +8 more
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Frontiers in Veterinary Science, 2022 Orexins A (OXA) and B (OXB) and the receptors 1 (OX1R) and 2 (OX2R) for orexins are hypothalamic peptides found in several mammalian organs and participated to the control of a wide assortment of physiological and pathological functions. The distribution
Caterina Squillacioti +8 more
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Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target
Molecules, 2021 Over 20 years ago, orexin neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) produced from the same precursor in hypothalamus were identified.
Couvineau Alain +3 more
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Evolution of Orexin Neuropeptide System: Structure and Function
Frontiers in Neuroscience, 2020 Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR).
Shingo Soya, Takeshi Sakurai
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Life, 2023 Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells.
Iman Mohammadi +5 more
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Asian Pacific Journal of Reproduction, 2019 Orexins (or hypocretins) are hypothalamic neuropeptides with a multitude of physiological functions. They occur in two known forms, namely, orexin A and orexin B with a common precursor, preproorexin. The orexin receptors (orexin 1R and orexin 2R) belong
Pallav Sengupta +3 more
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