Results 11 to 20 of about 6,131 (232)
The role of orexins/hypocretins in alcohol use and abuse: an appetitive-reward relationship [PDF]
Frontiers in Behavioral Neuroscience, 2012 Orexins (hypocretins) are neuropeptides synthesized in neurons located in the lateral, perifornical and dorsomedial hypothalamus. These neurons innervate many regions in the brain and modulate multiple other neurotransmitter systems. As a result of these
Andrezza Kyunmi Kim +3 more
doaj +3 more sources
Functional cardiac orexin receptors: role of orexin-B/orexin 2 receptor in myocardial protection [PDF]
Clinical Science, 2018 Orexins/hypocretins exert cardiovascular effects which are centrally mediated. In the present study, we tested whether orexins and their receptors may also act in an autocrine/paracrine manner in the heart exerting direct effects. Quantitative reverse transcription-PCR (RT-PCR), immunohistochemical and Western blot analyses revealed that the rat heart ...
Patel, V +12 more
openaire +11 more sources
Editorial: Hypocretins/Orexins
Frontiers in Endocrinology, 2020 Miguel López +4 more
doaj +3 more sources
Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor [PDF]
The Journal of Neuroscience, 2010 Orexin neurons (hypocretin neurons) have a critical role in the regulation of sleep/wakefulness, especially in the maintenance of arousal. Here, we revealed that orexin neurons are directly and indirectly activated by orexin via the orexin 2 receptor (OX2R).
Akihiro, Yamanaka +4 more
openaire +2 more sources
Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]
, 2013 The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
A Bisetti +53 more
core +7 more sources
Orexins in the clinical course of bipolar disorder
European Psychiatry, 2021 Introduction Orexins are involved in the regulation of circadian rhythms which play an important role in mood regulation(1,2), and are hypothesised to be associated with major depressive disorder(3).
C. Moya-Lacasa +4 more
doaj +1 more source
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 Objective To analyze the correlations between plasma orexin⁃A and clinical manifestations of dementia with Lewy bodies (DLB). Methods A total of 51 patients with DLB from Beijing Tiantan hospital, Capital Medical University, and 46 sex, age and ...
Yu⁃chen QIAO +5 more
doaj +1 more source
Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases
Frontiers in Endocrinology, 2019 Orexins [orexin-A (OXA) and orexin-B (OXB)] are two isoforms of neuropeptides produced by the hypothalamus. The main biological actions of orexins, focused on the central nervous system, are to control the sleep/wake process, appetite and feeding, energy
Alain Couvineau +5 more
doaj +1 more source
Genes and primary headaches: discovering new potential therapeutic targets [PDF]
, 2013 Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola +8 more
core +3 more sources
Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]
, 2015 Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David +17 more
core +1 more source