Results 1 to 10 of about 31,645 (116)

Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis [PDF]

Scientific Reports
Osteocytes regulate bone remodeling by interacting with osteoblasts and osteoclasts. Hypoxia influences osteocyte function and has been linked to increased osteoclastogenesis in pathological conditions such as orthodontic tooth movement (OTM) and bone ...
Kohei Narita, Fumitoshi Ohori, Aseel Marahleh, Jinghan Ma, Jiayi Ren, Angyi Lin, Ziqiu Fan, Kou Murakami, Hideki Kitaura   +8 more
doaj   +2 more sources

Bidirectional crosstalk between the bone extracellular matrix and lysosomes in bone remodeling and osteoporosis [PDF]

Frontiers in Endocrinology
Osteoporosis is a systemic skeletal disorder characterized by progressive loss of bone mass and deterioration of microarchitectural integrity. Traditionally, its pathogenesis has been attributed primarily to an imbalance in the number and activity of ...
Chang Zhou, Xinyue Hu, Yichen Jing, Jiaheng Zhang, Jing Tao, Xinyi Ouyang, Jiaqian Tang, Guomin Zhang, Huiping Liu   +8 more
doaj   +2 more sources

Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis

Advanced Science
Ferroptosis is a necrotic form of iron‐dependent regulatory cell death. Estrogen withdrawal can interfere with iron metabolism, which is responsible for the pathogenesis of postmenopausal osteoporosis (PMOP).
Hengfeng Yuan
exaly   +2 more sources

Reactive Oxygen Species (ROS) Drive Osteocyte Dysfunction in Diabetic Osteoporosis by Impairing Autophagy and Triggering Apoptosis [PDF]

Antioxidants
This study investigates the mechanisms underlying osteocyte injury in a high glucose (HG) environment and explores potential therapeutic targets and diagnostic markers for diabetic osteoporosis, a common complication of type 2 diabetes mellitus (T2DM ...
Mengqi Han, Minyue Zhao, Furong Bai, Mengying Wang, Bo Zhang, Jianfeng Shi, Zhongbo Liu   +6 more
doaj   +2 more sources

Single-cell RNA sequencing identifies Fgf23-expressing osteocytes in response to 1,25-dihydroxyvitamin D3 treatment

Frontiers in Physiology, 2023
Fibroblast growth factor 23 (FGF23), a hormone, mainly produced by osteocytes, regulates phosphate and vitamin D metabolism. By contrast, 1,25-dihydroxyvitamin D3, the active form of vitamin D, has been shown to enhance FGF23 production.
Ayako Hanai, Ayako Hanai, Ayako Kawabata, Kenta Nakajima, Kazuhiro Masuda, Itaru Urakawa, Masahiro Abe, Yuji Yamazaki, Seiji Fukumoto   +8 more
doaj   +1 more source

Differential Expression of Dickkopf 1 and Periostin in Mouse Strains with High and Low Bone Mass

Biology, 2022
By expressing different genes and proteins that regulate osteoclast as well as osteoblast formation, osteocytes orchestrate bone metabolism. The aim of this project was the evaluation of the differences in the osteocytes’ secretory activity in the low ...
Katharina Kerschan-Schindl, Victoria Schramek, Maria Butylina, Ursula Föger-Samwald, Peter Pietschmann   +4 more
doaj   +1 more source

Effect of High Static Magnetic Fields on Biological Activities and Iron Metabolism in MLO-Y4 Osteocyte-like Cells

Cells, 2021
There are numerous studies that investigate the effects of static magnetic fields (SMFs) on osteoblasts and osteoclasts. However, although osteocytes are the most abundant cell type in bone tissue, there are few studies on the biological effects of ...
Jiancheng Yang, Gejing Zhang, Qingmei Li, Qinghua Tang, Yan Feng, Peng Shang, Yuhong Zeng   +6 more
doaj   +1 more source

Extracellular Fe2+ and Fe3+ modulate osteocytic viability, expression of SOST, RANKL and FGF23, and fluid flow-induced YAP1 nuclear translocation

Scientific Reports, 2023
Iron overload negatively affects bone mass and strength. However, the impact of iron excess on osteocytes—important bone cells for mechanotransduction and remodeling—is poorly understood.
Wasutorn Chankamngoen, Saowalak Krungchanuchat, Jirawan Thongbunchoo, Naraporn Sirinonthanawech, Jarinthorn Teerapornpuntakit, Nattapon Panupinthu, Narattaphol Charoenphandhu   +6 more
doaj   +1 more source

Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone

Bone Research, 2021
Osteocytes are the most abundant cells in bone, which is a frequent site of breast cancer metastasis. Here, we focused on Wnt signaling and evaluated tumor-osteocyte interactions.
Shengzhi Liu, Di Wu, Xun Sun, Yao Fan, Rongrong Zha, Aydin Jalali, Yan Feng, Kexin Li, Tomohiko Sano, Nicole Vike, Fangjia Li, Joseph Rispoli, Akihiro Sudo, Jing Liu, Alexander Robling, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota   +17 more
doaj   +1 more source

Osteocytes Serve as a Reservoir for Intracellular Persisting Staphylococcus aureus Due to the Lack of Defense Mechanisms

Frontiers in Microbiology, 2022
Chronic staphylococcal osteomyelitis can persist for long time periods causing bone destruction. The ability of Staphylococcus aureus to develop chronic infections is linked to its capacity to invade and replicate within osteoblasts and osteocytes and to
Marina Garcia-Moreno, Paul M. Jordan, Kerstin Günther, Therese Dau, Christian Fritzsch, Monika Vermes, Astrid Schoppa, Anita Ignatius, Britt Wildemann, Oliver Werz, Bettina Löffler, Lorena Tuchscherr   +11 more
doaj   +1 more source