Results 11 to 20 of about 31,786 (255)

Osteocytes and Weightlessness [PDF]

Current Osteoporosis Reports, 2021
Abstract Purpose of Review Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions ...
Iandolo, Donata, Strigini, Maura, Guignandon, Alain, Vico, Laurence   +3 more
openaire   +4 more sources

Osteocyte Mechanobiology [PDF]

Current Osteoporosis Reports, 2017
Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells.Whereas increased mechanical forces promote bone formation ...
Yuhei, Uda, Ehab, Azab, Ningyuan, Sun, Chao, Shi, Paola Divieti, Pajevic   +4 more
openaire   +2 more sources

Osteocyte apoptosis [PDF]

Bone, 2013
Apoptotic death of osteocytes was recognized over 15 years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen deficiency and perhaps in other ...
Robert L, Jilka, Brendon, Noble, Robert S, Weinstein   +2 more
openaire   +2 more sources

Osteocyte Cellular Senescence [PDF]

Current Osteoporosis Reports, 2020
Senescent cells are now known to accumulate in multiple tissues with aging and through their inflammation (the senescence-associated secretory phenotype, SASP) contribute to aging and chronic diseases. Here, we review the roles of senescent osteocytes in the context of bone loss.Numerous studies have established that senescent osteocytes accumulate in ...
Joshua N. Farr, Japneet Kaur, Madison L. Doolittle, Sundeep Khosla   +3 more
openaire   +2 more sources

Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease

Frontiers in Endocrinology, 2023
IntroductionDue to a lack of spatial-temporal resolution at the single cell level, the etiologies of the bone dysfunction caused by diseases such as normal aging, osteoporosis, and the metabolic bone disease associated with chronic kidney disease (CKD ...
Rafiou Agoro, Intawat Nookaew, Megan L. Noonan, Yamil G. Marambio, Sheng Liu, Wennan Chang, Wennan Chang, Hongyu Gao, Hongyu Gao, Lainey M. Hibbard, Corinne E. Metzger, Daniel Horan, William R. Thompson, Xiaoling Xuei, Yunlong Liu, Yunlong Liu, Chi Zhang, Chi Zhang, Alexander G. Robling, Lynda F. Bonewald, Lynda F. Bonewald, Jun Wan, Kenneth E. White, Kenneth E. White   +23 more
doaj   +1 more source

Osteocyte: a Cellular Basis for Mechanotransduction in Bone

Journal of Biomechanical Science and Engineering, 2007
Osteocyte is the most abundant cell type in bone, and the only cell type located inside the mineralized matrix. The striking structural design of bone predicts an important role for osteocytes in determining bone structure and function.
Guoliang GU, Kosaku KURATA, Zhi CHEN, Kalervo H. VÄÄNÄNEN   +3 more
doaj   +1 more source

The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States

Frontiers in Cell and Developmental Biology, 2022
Bone homeostasis is a dynamic equilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts. This process is primarily controlled by the most abundant and mechanosensitive bone cells, osteocytes, that reside individually, within chambers of
Jung Un Ally Choi, Amanda W. Kijas, Jan Lauko, Alan E. Rowan   +3 more
doaj   +1 more source

CSF‐1 in Osteocytes Inhibits Nox4‐mediated Oxidative Stress and Promotes Normal Bone Homeostasis

JBMR Plus, 2020
CSF‐1 is a key factor in regulating bone remodeling; osteocytes express CSF‐1 and its receptor. Viable osteocytes are essential for bone remodeling through cell–cell contact and secretion of factors that regulate osteoblasts and osteoclasts.
Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug‐Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jiang   +11 more
doaj   +1 more source

The roles of osteocytes in alveolar bone destruction in periodontitis

Journal of Translational Medicine, 2020
Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis is crucial for understanding its pathogenesis.
Xiaofei Huang, Mengru Xie, Yanling Xie, Feng Mei, Xiaofeng Lu, Xiaoshuang Li, Lili Chen   +6 more
doaj   +1 more source

Identification of mechanics-responsive osteocyte signature in osteoarthritis subchondral bone

Bone & Joint Research, 2022
Aims: Osteoarthritis (OA) is a common degenerative joint disease. The osteocyte transcriptome is highly relevant to osteocyte biology. This study aimed to explore the osteocyte transcriptome in subchondral bone affected by OA.
Jun Zhou, Zhiyi He, Jiarui Cui, Xiaoling Liao, Hui Cao, Yo Shibata, Takashi Miyazaki, Jiaming Zhang   +7 more
doaj   +1 more source