Results 21 to 30 of about 31,786 (255)
Research progress on the relationship between osteocytes and periodontitis
口腔疾病防治, 2020 Osteocytes, which develop from osteoblasts, are recognized as the main cells embedded in mature bone tissue. The traditional notion is that osteocytes exclusively play a structural role, however, with the development of related research in recent years ...
ZHU Xuanzhi +3 more
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The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli
Frontiers in Bioengineering and Biotechnology, 2023 Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be necessary for skeletal growth and health and to play a role in actin-based ...
Beth S. Lee +9 more
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Journal of Bone and Mineral Research, 2010 Abstract The last decade has provided a virtual explosion of data on the molecular biology and function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been found to have numerous functions, such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity ...
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Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement
Journal of Immunology Research, 2019 Osteocytes are abundant cells in bone, which contribute to bone maintenance. Osteocytes express receptor activator of nuclear factor kappa-B ligand (RANKL) and regulate osteoclast formation.
Fumitoshi Ohori +9 more
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Current Osteoporosis Reports, 2023 Abstract Purpose of Review The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing. Recent Findings Osteocytes are thought to be the primary mechanosensing cells in bone tissue ...
Verbruggen, S.W. +2 more
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TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation
Frontiers in Immunology, 2019 Osteoimmunology peeks into the interaction of bone and the immune system, which has largely proved to be a multiplex reaction. Osteocytes have been shown to regulate bone resorption through the expression of RANKL in physiologic and pathologic conditions.
Aseel Marahleh +9 more
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Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice
Biomedicines, 2022 Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, their long-term use leads to glucocorticoid-induced osteoporosis, increasing morbidity and mortality. Both anabolic and anti-resorptive drugs are used to counteract GC-induced
Benjamin Thilo Krüger +8 more
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Osteocytes and Bone Metastasis [PDF]
Frontiers in Endocrinology, 2020 Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of the most common sites of metastasis for many solid tumors. Once cancer cells colonize in the bone, it imposes a major clinical challenge for the treatment of the disease, and fatality rates increase drastically.
Manuel A. Riquelme +2 more
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Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice
BioTechniques, 2012 The purpose of this work was to establish a methodology to enable the isolation and study of osteocytes from skeletally mature young (4-month-old) and old (22-month-old) mice.
Amber Rath Stern +5 more
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Frontiers in Bioengineering and Biotechnology, 2020 Recent in vitro studies have revealed that the mechanobiological responses of osteoblasts and osteocytes are fundamentally impaired during estrogen deficiency.
Syeda Masooma Naqvi +4 more
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