Diazocarbonyl and Related Compounds in the Synthesis of Azoles
Molecules, 2021 Diazocarbonyl compounds have found numerous applications in many areas of chemistry. Among the most developed fields of diazo chemistry is the preparation of azoles from diazo compounds.
Anton Budeev +3 more
doaj +1 more source
Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles [PDF]
, 2017 New coumarin fused oxazoles were investigated as photosensitive units for carboxylic acid groups using butyric acid as a model compound. 6-Oxo-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl derivatives possessing various (hetero)aromatic substituents at ...
Ana M.S. Soares +36 more
core +1 more source
Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. [PDF]
, 2016 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (PA-824).
Blaser, Adrian +12 more
core +3 more sources
Naturally Occurring Oxazole-Containing Peptides [PDF]
Marine Drugs, 2020 Oxazole-containing peptides are mostly of marine origin and they form an intriguing family with a broad range of biological activities. Here we classify these peptides on the basis of their chemical structure and discuss a number of representatives of each class that reflect the extraordinary potential of this family as a source of new drugs.
Jessica T. Mhlongo +3 more
openaire +3 more sources
Continuous multistep synthesis of 2-(azidomethyl)oxazoles
Beilstein Journal of Organic Chemistry, 2018 An efficient three-step protocol was developed to produce 2-(azidomethyl)oxazoles from vinyl azides in a continuous-flow process. The general synthetic strategy involves a thermolysis of vinyl azides to generate azirines, which react with bromoacetyl ...
Thaís A. Rossa +4 more
doaj +1 more source
Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands [PDF]
, 2013 Using a phenotypic screening and SAR optimization approach, a phenyl-bis-oxazole derivative has been identified with anti-proliferative activity, optimized with the use of a panel of cancer cell lines.
CIANCIMINO, Cristina +4 more
core +1 more source
Gold Catalyzed Multicomponent Reactions beyond A3 Coupling
Molecules, 2018 The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity.
Renso Visbal +3 more
doaj +1 more source
Molecules, 2022 An efficient, versatile, and one-pot method for the preparation of novel fluorinated thiazolo- and oxazolo[3,2-a]pyrimidin-7-ones is described from 2-aminothiazoles or 2-amino-oxazoles and fluorinated alkynoates.
Wafa Blancou +4 more
doaj +1 more source
1,4- Addition of diazomethane to a heterodiene: a direct preparation of the oxazolic ring
Anais da Academia Brasileira de Ciências, 2007 The reaction of naphthoquinone-oximes (3) and (4) with diazomethane yields directly, in one step, the oxazoles (5) and (6), respectively.A reação das naphthoquinona-oximas (3) e (4) com diazometano fornece diretamente, em uma etapa, os oxazóis (5) e (6),
Flávio da S. Emery +9 more
doaj +1 more source
Total synthesis of the post-translationally modified polyazole peptide antibiotic goadsporin [PDF]
, 2017 The structurally unique polyazole antibiotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear array of amino acids that also contains two dehydroalanine residues.
Arnison +22 more
core +2 more sources