Results 61 to 70 of about 29,607 (257)

Atypical hepatitis B surface antigen escape mutations in an HIV-positive patient in South Africa

Southern African Journal of Infectious Diseases
A 44-year-old woman with human immunodeficiency virus (HIV), chronic kidney disease and chronic diarrhoea presented with worsening gastrointestinal symptoms and renal impairment.
Menzi B. Nkosi, Marije van Schalkwyk, Tongai G. Maponga, Yoliswa Z. Chili, Devon Muir, Paula R. Delport, Susan S. Hugo, Zahiera Ismail, Jantjie Taljaard, Gert U. van Zyl, Wolfgang Preiser   +10 more
doaj   +1 more source

Nanopore Sequencing in Blood Diseases: A Wide Range of Opportunities

Frontiers in Genetics, 2020
The molecular pathogenesis of hematological diseases is often driven by genetic and epigenetic alterations. Next-generation sequencing has considerably increased our genomic knowledge of these disorders becoming ever more widespread in clinical practice.
Crescenzio Francesco Minervini, Cosimo Cumbo, Paola Orsini, Luisa Anelli, Antonella Zagaria, Giorgina Specchia, Francesco Albano   +6 more
doaj   +1 more source

DeepNano: Deep recurrent neural networks for base calling in MinION nanopore reads. [PDF]

PLoS ONE, 2017
The MinION device by Oxford Nanopore produces very long reads (reads over 100 kBp were reported); however it suffers from high sequencing error rate.
Vladimír Boža, Broňa Brejová, Tomáš Vinař   +2 more
doaj   +1 more source

Performance of neural network basecalling tools for Oxford Nanopore sequencing [PDF]

Genome Biology, 2019
Abstract Basecalling, the computational process of translating raw electrical signal to nucleotide sequence, is of critical importance to the sequencing platforms produced by Oxford Nanopore Technologies (ONT). Here we examine the performance of different basecalling tools, looking at accuracy at the level of bases within individual ...
Wick, Ryan R., Judd, Louise M., Holt, Kathryn E.   +2 more
openaire   +4 more sources

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

Rapid prenatal CNV detection using nanopore technology

BMC Research Notes
Rapid identification of copy-number variations (CNVs) is crucial in prenatal diagnosis; however, current chromosomal microarray analysis (CMA) has a lengthy turnaround time. We evaluated the feasibility of low-pass nanopore sequencing for genome-wide CNV
Maolee Bhuwapathanapun, Piya Chaemsaithong, Puntabut Warintaksa, Budsaba Rerkamnuaychoke, Rachanee Parinayok, Takol Chareonsirisuthigul, Suwatcharaporn Hadradchai, Maneerat Prakobpanich, Weerin Thammachote, Natini Jinawath, Tantip Arigul, Pattaraporn Nimsamer, Sopacha Arayamethakorn, Sorawee Kaewkarn, Piroon Jenjaroenpun, Thidathip Wongsurawat   +15 more
doaj   +1 more source

Pike: OTU-Level Analysis for Oxford Nanopore Amplicon Metagenomics. [PDF]

Int J Mol Sci
The Oxford Nanopore platform and nanopore sequencing are gaining increasing popularity in modern metagenomic research. However, there is a limited set of dedicated tools for analyzing this type of data. The tools used for nanopore amplicon sequencing data analysis often provide only taxonomy annotation without OTU sequence assembly.
Krivonos DV, Fedorov DE, Konanov DN, Vvedensky AV, Sonets IV, Korneenko EV, Speranskaya AS, Ilina EN.   +7 more
europepmc   +3 more sources

The use of Oxford Nanopore native barcoding for complete genome assembly [PDF]

GigaScience, 2017
Abstract Background The Oxford Nanopore Technologies MinION(TM) is a mobile DNA sequencer that can produce long read sequences with a short turn-around time. Here we report the first demonstration of single contig genome assembly using Oxford Nanopore native barcoding when applied to a multiplexed ...
Bayliss, Sion C., Hunt, Vicky L., Yokoyama, Maho, Thorpe, Harry A., Feil, Edward J.   +4 more
openaire   +3 more sources

Revolutionising Agricultural Sustainability: New ‘Furrow Tillage’ can Mitigate Short‐Term Soil‐to‐Atmosphere CO2 Flux and Promote Soil‐Plant‐Microbe Health

Advanced Science, EarlyView.
Furrow tillage resolves the conventional‐vs.‐no‐tillage trade‐off by simultaneously cutting CO2 efflux to 2.0–3.0 g C m−2 d−1 and unlocking high nutrient availability for the rice rhizosphere. This scalable agronomic solution strengthens soil health, enhances plant physiology, reshapes microbial metabolism, and shifts paddy systems toward a net ...
Arnab Majumdar, Munish Kumar Upadhyay, Argha Ghosh, Rakesh Biswas, Ioly Kotta Loizou, Martin Buck, Mark Tibbett, Biswajit Giri, Debojyoti Moulick, Manoj Kumar Jaiswal, Tarit Roychowdhury   +10 more
wiley   +1 more source