Results 1 to 10 of about 12,157 (98)
Ion channel P2X7 receptor in the progression of cancer [PDF]
Frontiers in Oncology, 2023 P2X7 receptor (P2X7) is a non-selective and ATP-sensitive ligand-gated cation channel. Studies have confirmed that it is expressed in a variety of cells and correlates with their function, frequently in immune cells and tumor cells.
Guang-ping Zhang +6 more
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Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder [PDF]
Brain, Behavior, & Immunity - HealthAutism spectrum disorder (ASD) is a common developmental neurological disorder that has a significant genetic predisposition and is marked by an early beginning of impairment of social communication and restricted repetitive behaviors, as well as loss of
Chetana Ahire, Ginpreet Kaur
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P2X7 receptor in inflammation and pain
Brain Research Bulletin, 2022 Different studies have confirmed P2X7 receptor-mediated inflammatory mediators play a key role in the development of pain. P2X7 receptor activation can induce the development of pain by mediating the release of inflammatory mediators. In view of the fact
Shi-qi Hu +7 more
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Frontiers in Immunology, 2022 The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage.
Stephanie Alexia Cristina Silva Santos +10 more
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Frontiers in Molecular Neuroscience, 2020 The ionotropic ATP-gated P2X7 receptor is an important contributor to inflammatory signaling cascades via the release of Interleukin-1β, as well as having roles in cell death, neuronal plasticity and the release of neurotransmitters.
Giorgia Conte +11 more
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Frontiers in Pharmacology, 2021 Inflammatory conditions of the urinary bladder have been shown to be associated with urothelial damage and loss of function. The purinergic P2X7 receptor has been implicated in several inflammatory conditions. The aim of this study was to investigate the
Zhinoos Taidi +4 more
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The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis
Frontiers in Cellular Neuroscience, 2021 Microglial cells regulate neural homeostasis by coordinating both immune responses and clearance of debris, and the P2X7 receptor for extracellular ATP plays a central role in both functions.
Keith E. Campagno +3 more
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The P2X7 Receptor: Central Hub of Brain Diseases
Frontiers in Molecular Neuroscience, 2020 The P2X7 receptor is a cation channel activated by high concentrations of adenosine triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming a wide pore that leads to cell death and increased release of ATP into the ...
Roberta Andrejew +6 more
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Effect of P2X7 receptor knockout on AQP-5 expression of type I alveolar epithelial cells. [PDF]
PLoS ONE, 2014 P2X7 receptors, ATP-gated cation channels, are specifically expressed in alveolar epithelial cells. The pathophysiological function of this lung cell type, except a recently reported putative involvement in surfactant secretion, is unknown.
Georg Ebeling +5 more
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Frontiers in Immunology, 2022 Inflammation is a tightly coordinated response against bacterial and viral infections, triggered by the production of pro-inflammatory cytokines. SARS-CoV-2 infection induces COVID-19 disease, characterized by an inflammatory response mediated through ...
Julio García-Villalba +8 more
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