Results 11 to 20 of about 12,246 (181)
P2X7 Receptor in Hematological Malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2021 The P2X7 receptor is an ion channel gated by the nucleotide ATP, known for its role in immune responses and recently emerging as a critical onco-promoting factor.
Elena De Marchi +2 more
doaj +4 more sources
P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease [PDF]
Frontiers in Pharmacology, 2021 Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou +9 more
doaj +3 more sources
P2X7 Receptor Function in Bone-Related Cancer [PDF]
Journal of Osteoporosis, 2012 Modulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host ...
Elena Adinolfi +2 more
doaj +4 more sources
The P2X7 Receptor in Osteoarthritis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is the most common joint disease. With the increasing aging population, the associated socio-economic costs are also increasing. Analgesia and surgery are the primary treatment options in late-stage OA, with drug treatment only possible in early prevention to improve patients’ quality of life. The most important structural component
Zihao Li, Ziyu Huang, Lunhao Bai
openaire +3 more sources
The P2X7 Receptor in Autoimmunity. [PDF]
Int J Mol Sci, 2023 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues.
Grassi F, Salina G.
europepmc +4 more sources
The P2X7 Receptor in Tumor Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair.
Fabio Grassi +2 more
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Chlamydia psittaci inhibits apoptosis of human neutrophils by activating P2X7 receptor expression
International Journal of Medical Microbiology, 2022 This study tested the hypothesis that Chlamydia psittaci (C. psittaci) survives and multiplies in human neutrophils by activating P2X7, a nonselective cationic channel receptor expressed constitutively on the surface of these cells.
Zhangping He +11 more
doaj +1 more source
Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors [PDF]
Journal of Biological Chemistry, 2003 The purinergic P2X7 receptor not only gates the opening of a cationic channel, but also couples to several downstream signaling events such as rapid membrane blebbing, microvesicle shedding, and interleukin-1beta release. Protein-protein interactions are likely to be involved in most of these signaling cascades; and recently, a P2X7 receptor-protein ...
ADINOLFI, Elena +4 more
openaire +5 more sources
Dissecting activation steps in P2X7 receptors
Biochemical and Biophysical Research Communications, 2021 P2X7 receptors are trimeric ion channels activated by extracellular ATP. Upon activation, they trigger cytolysis and apoptosis but also control cell proliferation. To shed more light on channel gating and the underlying function of the individual subunits, receptors of concatenated subunits were built containing a defined number of functional binding ...
Milica Gusic +2 more
openaire +2 more sources
Cell Death and Disease, 2021 Extracellular adenosine triphosphate (ATP) and its receptor, P2X7 receptor (P2X7R), are playing an important role in the pathological process of renal ischemia-reperfusion injury, but their underlying mechanism remains unclear.
Yingying Qian +13 more
doaj +1 more source