Results 21 to 30 of about 12,246 (181)

Role of P2X7 Receptors in Immune Responses During Neurodegeneration

Frontiers in Cellular Neuroscience, 2021
P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytokine ...
Ágatha Oliveira-Giacomelli, Lyvia Lintzmaier Petiz, Roberta Andrejew, Natalia Turrini, Jean Bezerra Silva, Ulrich Sack, Henning Ulrich, Henning Ulrich   +7 more
doaj   +1 more source

Radioligands targeting purinergic P2X7 receptor [PDF]

Bioorganic & Medicinal Chemistry Letters, 2020
The purinergic P2X7 receptor (P2X7R) is an adenosine triphosphate (ATP) ligand-gated cationic channel receptor. P2X7R is closely associated with various inflammatory, immune, cancer, neurological, musculoskeletal and cardiovascular disorders. P2X7R is an interesting therapeutic target as well as molecular imaging target.
openaire   +2 more sources

The P2X7 Receptor-Interleukin-1 Liaison [PDF]

Frontiers in Pharmacology, 2017
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g., auto-inflammatory syndromes, as well as common pathologies, such as type II diabetes, gout and atherosclerosis.
GIULIANI, Anna Lisa, SARTI, Alba Clara, FALZONI, Simonetta, DI VIRGILIO, Francesco   +3 more
openaire   +3 more sources

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors [PDF]

British Journal of Pharmacology, 2009
Background and purpose: Acute activation of P2X7 receptors rapidly opens a non‐selective cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, mediated by downstream recruitment of hemichannels to the cell surface.
Diana L, Donnelly-Roberts, Marian T, Namovic, Ping, Han, Michael F, Jarvis   +3 more
openaire   +2 more sources

P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells

Cell Death and Disease, 2021
Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor stimulation is known to trigger vesicular release from immune and central nervous
Anna Pegoraro, Elena De Marchi, Manuela Ferracin, Elisa Orioli, Michele Zanoni, Cristian Bassi, Anna Tesei, Marina Capece, Emi Dika, Massimo Negrini, Francesco Di Virgilio, Elena Adinolfi   +11 more
doaj   +1 more source

Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death

Frontiers in Immunology, 2018
Adenosine triphosphate (ATP) is known to induce cell death in T lymphocytes at high extracellular concentrations. CD4+ and CD8+ T lymphocytes have a differential response to ATP, which in mice is due to differences in the P2X7 receptor expression levels.
Karin Dreisig, Louise Sund, Maja Wallentin Dommer, Nikolaj Pagh Kristensen, Kim Boddum, Rannveig Viste, Simon Fredholm, Niels Odum, Marja Jäättelä, Søren Skov, Birgitte R. Kornum, Birgitte R. Kornum   +11 more
doaj   +1 more source

P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Frontiers in Immunology, 2017
Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain ...
Maria Barberà-Cremades, Ana I. Gómez, Alberto Baroja-Mazo, Laura Martínez-Alarcón, Carlos M. Martínez, Carlos de Torre-Minguela, Pablo Pelegrín   +6 more
doaj   +1 more source

The P2X7 Receptor, a Multifaceted Receptor in Alzheimer's Disease. [PDF]

Int J Mol Sci, 2023
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by impaired episodic memory and two pathological lesions: amyloid plaques and neurofibrillary tangles. In AD, damaged neurons and the accumulation of amyloid β (Aβ) peptides cause a significant release of high amounts of extracellular ATP, which acts as a danger signal ...
Ronning KE, Déchelle-Marquet PA, Che Y, Guillonneau X, Sennlaub F, Delarasse C.   +5 more
europepmc   +3 more sources

Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.

PLoS ONE, 2012
The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by neurons and plays a role as a neurotransmitter receptor has been the subject of controversy.
Kirstan A Vessey, Erica L Fletcher
doaj   +1 more source

P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

Frontiers in Pharmacology, 2020
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response.
Romain Lara, Elena Adinolfi, Catherine A. Harwood, Mike Philpott, Julian A. Barden, Francesco Di Virgilio, Shaun McNulty   +6 more
doaj   +1 more source