Results 31 to 40 of about 12,246 (181)
Cells, 2022 In pregnant women, the lungs, skin and placenta are exposed daily to endocrine-disrupting chemicals (EDCs). EDCs induce multiple adverse effects, not only on endocrine organs, but also on non-endocrine organs, with the P2X7 cell death receptor being ...
Sophie Fouyet +4 more
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Journal of Osteoporosis, 2012 P2X7 receptor-mediated purinergic signaling is a well-known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and ...
Alberto Baroja-Mazo, Pablo Pelegrín
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P2X7 Receptors: Channels, Pores and More
CNS & Neurological Disorders - Drug Targets, 2012 Purine nucleotides are well established as extracellular signaling molecules. P2X7 receptors (P2X7Rs) are members of the family of ionotropic ATP-gated receptors. Their activity can be found in a limited number of cell types, but is readily detectable in cells of hemopoietic lineage including macrophages, microglia, and certain lymphocytes, and ...
Volont('e), C. +3 more
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Journal of Neuroinflammation, 2021 Background The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expressed
Keith E. Campagno +9 more
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Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells
Toxicology Reports, 2015 Ultraviolet A (UVA) radiation, the major UV component of solar radiation, can penetrate easily to the dermis, where it causes significant damage to cellular components by inducing formation of reactive oxygen species (ROS).
Ayumi Kawano +4 more
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PLoS Pathogens, 2017 A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria.
Érika Machado de Salles +13 more
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P2X7 Receptor Upregulation in Huntington’s Disease Brains [PDF]
Frontiers in Molecular Neuroscience, 2020 Huntington's disease (HD) is a fatal degenerative disorder affecting the nervous system. It is characterized by motor, cognitive, and psychiatric dysfunctions, with a late onset and an autosomal dominant pattern of inheritance. HD-causing mutation consists in an expansion of repeated CAG triplets in the huntingtin gene (HTT), encoding for an expanded ...
Ivana Ollà +7 more
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The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation. [PDF]
PLoS ONE, 2013 The P2X7 receptor binds extracellular ATP to mediate numerous inflammatory responses and is considered a potential biomarker and therapeutic target for diverse inflammatory and neurological diseases.
Lisa E Wickert +6 more
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Frontiers in Cellular Neuroscience, 2021 Purinergic receptors play important roles in central nervous system (CNS), where the bulk of these receptors are implicated in neuroinflammatory responses and regulation of cellular function of neurons, microglial and astrocytes.
Paul R. Territo +2 more
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P2X7 Receptor and Extracellular Vesicle Release
International Journal of Molecular Sciences, 2023 Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells ...
Golia, Maria Teresa +2 more
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