Results 51 to 60 of about 12,246 (181)

The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

Frontiers in Pharmacology, 2018
Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the extracellular milieu, being massively released by stressed or dying cells.
Luiz E. B. Savio, Paola de Andrade Mello, Cleide Gonçalves da Silva, Robson Coutinho-Silva   +3 more
doaj   +1 more source

The P2X7 receptor supports both life and death in fibrogenic pancreatic stellate cells. [PDF]

PLoS ONE, 2012
The pancreatic stellate cells (PSCs) have complex roles in pancreas, including tissue repair and fibrosis. PSCs surround ATP releasing exocrine cells, but little is known about purinergic receptors and their function in PSCs.
Kristian A Haanes, Albrecht Schwab, Ivana Novak   +2 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy

Immunobiology
Background: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor ...
Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui   +5 more
doaj   +1 more source

Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4.

PLoS Pathogens, 2019
Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide. P2X7 receptor has been linked to the elimination of Leishmania amazonensis.
Mariana M Chaves, Debora A Sinflorio, Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Aline Cristina Abreu Moreira-Souza, Thuany Prado Rangel, Claudia L M Silva, Maria Bellio, Claudio Canetti, Robson Coutinho-Silva   +9 more
doaj   +1 more source

Interaction of Purinergic P2X4 and P2X7 Receptor Subunits

Frontiers in Pharmacology, 2017
P2X4 and P2X7 are members of the P2X receptor family, comprising seven isoforms (P2X1–P2X7) that form homo- and heterotrimeric non-specific cation channels gated by extracellular ATP.
Markus Schneider, Kirsten Prudic, Anja Pippel, Manuela Klapperstück, Ursula Braam, Christa E. Müller, Günther Schmalzing, Fritz Markwardt   +7 more
doaj   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, EarlyView.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Procedures to characterize and study P2Z/P2X7 purinoceptor: flow cytometry as a promising practical, reliable tool

Memorias do Instituto Oswaldo Cruz, 2000
The expression of P2Z/P2X7 purinoceptor in different cell types is well established. This receptor is a member of the ionotropic P2X receptor family, which is composed by seven cloned receptor subtypes (P2X1 - P2X7).
Nihei Oscar Kenji, Savino Wilson, Alves Luiz Anastacio   +2 more
doaj  

P2X7 Interactions and Signaling – Making Head or Tail of It

Frontiers in Molecular Neuroscience, 2019
Extracellular adenine nucleotides play important roles in cell–cell communication and tissue homeostasis. High concentrations of extracellular ATP released by dying cells are sensed as a danger signal by the P2X7 receptor, a non-specific cation channel ...
Robin Kopp, Anna Krautloher, Antonio Ramírez-Fernández, Annette Nicke   +3 more
doaj   +1 more source

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source