Results 11 to 20 of about 5,309 (159)

Identification of Pannexins in Rat Nasal Mucosa

Allergy & Rhinology, 2013
Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D., Nobusuke Hohchi M.D., Jun-ichi Ohkubo M.D., Koichi Hashida M.D., Hiroki Koizumi M.D., Tetsuro Wakasugi M.D., Fumiko Takenaga M.D., Hideaki Suzuki M.D., Ph.D.   +7 more
doaj   +3 more sources

The Pannexins: Past and Present [PDF]

Frontiers in Physiology, 2014
The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Steven eBond, Steven eBond, Christian C. Naus   +2 more
doaj   +3 more sources

Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms

Nature Communications
Pannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain, Ashish Apotikar, Shabareesh Pidathala, Sourajit Mukherjee, Ananth Prasad Burada, Sujit Kumar Sikdar, Kutti R. Vinothkumar, Aravind Penmatsa   +7 more
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Pharmacology of pannexin channels

Current Opinion in Pharmacology, 2023
Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the ability to pharmacologically block these channels is a vital component of several therapeutic approaches.
Michael Koval, Wyatt J. Schug, Brant E. Isakson   +2 more
openaire   +2 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]

J Trop Med
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc   +2 more sources

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation [PDF]

Journal of Cell Science, 2010
Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In
Steven J, Celetti, Kyle N, Cowan, Silvia, Penuela, Qing, Shao, Jared, Churko, Dale W, Laird   +5 more
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Gap junctions, pannexins and pain [PDF]

Neuroscience Letters, 2019
Enhanced expression and function of gap junctions and pannexin (Panx) channels have been associated with both peripheral and central mechanisms of pain sensitization. At the level of the sensory ganglia, evidence includes augmented gap junction and pannexin1 expression in glial cells and neurons in inflammatory and neuropathic pain models and increased
David C, Spray, Menachem, Hanani
openaire   +2 more sources

Pannexins in the vasculature. [PDF]

Am J Physiol Heart Circ Physiol
Pannexins (PANX1, PANX2, PANX3) are a family of large-pore, ion and metabolite channels present throughout the blood and lymphatic vascular networks. PANX1 has near-ubiquitous expression in the cardiovascular system and is the most highly studied pannexin in both homeostatic and disease conditions.
O'Donnell BL, Williams MD, Billaud M, Dunaway LS, Columbus L, Koval M, Isakson BE.   +6 more
europepmc   +3 more sources

Human stem cells express pannexins [PDF]

BMC Research Notes, 2018
Pannexins are channel proteins important for the release of calcium and adenosine triphosphate, which are among other functions involved in early development. Here, the expression of pannexins was investigated in induced pluripotent stem cells derived from human cord blood endothelial cells (hCBiPS2), in hematopoietic stem cell-derived induced ...
Nadine Hainz, Anja Beckmann, Madline Schubert, Alexandra Haase, Ulrich Martin, Thomas Tschernig, Carola Meier   +6 more
openaire   +3 more sources

Pannexins in Acute Kidney Injury [PDF]

Nephron, 2019
Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently effluxes ATP and plays a central role in the progression of inflammatory ...
Nabin, Poudel, Mark D, Okusa
openaire   +2 more sources