Results 21 to 30 of about 5,309 (159)

Pannexin channels in the kidney. [PDF]

Am J Physiol Renal Physiol
Renal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney disease subtypes is incompletely understood; therefore, many patients progress to kidney failure, needing dialysis ...
Williams MD, O'Donnell BL, Columbus L, DeLalio LJ, Erdbrügger U, Isakson BE.   +5 more
europepmc   +2 more sources

Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease. [PDF]

Compr Physiol
The vascular endothelium is highly diverse, regulating permeability, vascular tone, repair, and inter‐organ communication. Endothelial heterogeneity supports tissue‐specific needs, but dysfunction drives cardiovascular disease. Transcriptomics, in vitro models, and redox signaling studies reveal therapeutic targets for precision treatment of ...
Williams AE, Dunaway LS, Juśkiewicz ZJ, Schug WJ, Cortese-Krott MM, Koval M, Isakson BE.   +6 more
europepmc   +2 more sources

Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation

Neural Development, 2012
Background Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain. After discovering pannexin 1 expression in postnatal neural stem and progenitor cells we sought to elucidate its functional role in ...
Wicki-Stordeur Leigh E, Dzugalo Adrian D, Swansburg Rose M, Suits Jocelyne M, Swayne Leigh   +4 more
doaj   +1 more source

Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization [PDF]

Cell Communication & Adhesion, 2013
Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking. Panx2, another family member, has a longer and highly dissimilar C-terminus.
Leigh E, Wicki-Stordeur, Andrew K J, Boyce, Leigh Anne, Swayne   +2 more
openaire   +2 more sources

Pannexin-1 Channels as Mediators of Neuroinflammation [PDF]

International Journal of Molecular Sciences, 2021
Neuroinflammation is a major component of central nervous system (CNS) injuries and neurological diseases, including Alzheimer’s disease, multiple sclerosis, neuropathic pain, and brain trauma. The activation of innate immune cells at the damage site causes the release of pro-inflammatory cytokines and chemokines, which alter the functionality of ...
Seo, Joon Ho, Dalal, Miloni S, Contreras, Jorge E   +2 more
openaire   +4 more sources

Perspectives on the role of Pannexin 1 in neural precursor cell biology

Neural Regeneration Research, 2016
We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous
Juan C Sanchez-Arias, Leigh E Wicki-Stordeur, Leigh Anne Swayne   +2 more
doaj   +1 more source

The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

eLife, 2020
Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins ...
Kevin Michalski, Johanna L Syrjanen, Erik Henze, Julia Kumpf, Hiro Furukawa, Toshimitsu Kawate   +5 more
doaj   +1 more source

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

Frontiers in Cellular Neuroscience, 2017
The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton, Carlos Luna Lopez, Elisabeth Blevins, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I. Shestopalov, Helen P. Makarenkova, Sameer B. Shah, Sameer B. Shah, Sameer B. Shah   +10 more
doaj   +1 more source

Pannexin channels and ischaemia [PDF]

The Journal of Physiology, 2014
AbstractAn ischaemic stroke occurs during loss of blood flow in the brain from the occlusion of a blood vessel. The ischaemia itself comprises a complex array of insults, including oxygen and glucose deprivation (OGD), glutamate excitotoxicity, acidification/hypercapnia, and loss of sheer forces.
openaire   +2 more sources

Pannexins in ischemia-induced neurodegeneration [PDF]

Proceedings of the National Academy of Sciences, 2011
Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a potential contribution of pannexins in ischemia-related mechanisms, we performed experiments in
Bargiotas, Panagiotis, Krenz, Antje, Hormuzdi, Sheriar G., Ridder, Dirk A., Herb, Anne, Barakat, Waleed, Penuela, Silvia, von Engelhardt, Jakob, Monyer, Hannah, Schwaninger, Markus   +9 more
openaire   +3 more sources