Results 61 to 70 of about 5,309 (159)
Cell Proliferation, Volume 59, Issue 2, February 2026.Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu +8 more
wiley +1 more source
Knockout of Pannexin-1 Induces Hearing Loss [PDF]
International Journal of Molecular Sciences, 2018 Mutations of gap junction connexin genes induce a high incidence of nonsyndromic hearing loss. Pannexin genes also encode gap junctional proteins in vertebrates. Recent studies demonstrated that Pannexin-1 (Panx1) deficiency in mice and mutation in humans are also associated with hearing loss.
Chen, Jin +4 more
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Involvement of gap junction channels in the pathophysiology of migraine with aura
Frontiers in Physiology, 2014 Migraine is a common, recurrent and disabling primary headache disorder with a genetic component which affects up to 20 % of the population. One third of all patients with migraine experiences aura, a focal neurological disturbance that manifests itself ...
Denis eSarrouilhe +2 more
doaj +1 more source
Genes, Brain and Behavior, Volume 25, Issue 1, February 2026.Buccal ganglia inter‐ and motoneuronal transcriptional changes were investigated after learning food is inedible (LFI) in Aplysia californica reared on different diets at two ages. Those reared on calorie restriction showed delayed signs of aging and maintained their performance in LFI when aged while those reared on ad‐lib did not. ABSTRACT Along with
Eric C. Randolph, Lynne A. Fieber
wiley +1 more source
Innexins: Expression, Regulation, and Functions
Frontiers in Physiology, 2018 The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes.
Juan Güiza +4 more
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 4, Page 1592-1606, 15 February 2026.Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu +2 more
wiley +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Connexins and pannexins in liver damage
EXCLI journal, 2016 EXCLI Journal;Vol.
Crespo Yanguas, Sara +7 more
openaire +4 more sources
The cellular life of pannexins [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractThe mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2, and Panx3 has received considerable attention in the last 10 years given their newly discovered physiological roles in development and disease. Pannexins exhibit diverse subcellular profiles indicating that they may serve distinct roles in cells and tissues of
Silvia Penuela, Dale W. Laird
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Advanced Science, Volume 13, Issue 1, 5 January 2026.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source