Results 71 to 80 of about 5,309 (159)
S-Nitrosylation Inhibits Pannexin 1 Channel Function [PDF]
Journal of Biological Chemistry, 2012 S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity.
Alexander W, Lohman +10 more
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The two faces of pannexins: new roles in inflammation and repair
Journal of Inflammation Research, 2018 Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj
Relevance of Gap Junctions and Large Pore Channels in Traumatic Brain Injury
Frontiers in Physiology, 2014 In case of traumatic brain injury (TBI), occurrence of central nervous tissue damage is frequently aligned with local modulations of neuronal and glial gap junction channel expression levels.
Nora eProchnow
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Investigation of olfactory function in a Panx1 knock out mouse model
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation.
Stefan eKurtenbach +7 more
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Mediators of Inflammation, Volume 2026, Issue 1, 2026.Metabolic reorganization and chronic inflammation are dynamic and diverse events in the tumor microenvironment (TME) that cause tumor propagation, spreading, and resistance to treatment. However, copper‐induced cell death (cuproptosis), which is a newly discovered form of regulated cell death (RCD) induced by high intracellular copper ions and is a ...
Yan Wang +6 more
wiley +1 more source
Mechanism of GSDMD in the Pathogenesis of Pasteurella multocida PmCQ2
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.Pasteurella multocida serotype A (PmCQ2), a Gram‐negative zoonotic pathogen, causes severe respiratory disease in a variety of domestic and wild animals, leading to high morbidity and mortality and substantial agricultural economic losses. Pyroptosis, a gasdermin‐mediated programmed cell death mechanism, facilitates pathogen clearance but exacerbates ...
Qingqing Yang +8 more
wiley +1 more source
Molecular pathways of pannexin1-mediated neurotoxicity
Frontiers in Physiology, 2014 Pannexin1 (Panx1) forms nonselective membrane channels, structurally similar to gap junction hemichannels, that is permeable to ions, nucleotides and other small molecules below 900 Da. Panx1 activity is implicated in paracrine signaling and inflammasome
Valery I. Shestopalov +4 more
doaj +1 more source
Biomolecules, 2020 Pannexin 1 (Panx1) is a ubiquitously expressed hexameric integral membrane protein known to function as an adenosine triphosphate (ATP) release channel. Panx1 proteins exist in unglycosylated core form (Gly0).
Ksenia Timonina +2 more
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Advanced Science, Volume 12, Issue 45, December 4, 2025.Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang +17 more
wiley +1 more source
Pannexin Channel Inhibition [PDF]
Circulation Research, 2018 More than 50 years after spironolactone has come on the market its mechanism of action continues to expand. In this issue of Circulation Research , Good et al1 document the discovery that spironolactone is not only an inhibitor of the mineralocorticoid receptor but also inhibits pannexin 1 channels.
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