Results 81 to 90 of about 5,309 (159)
A taste for ATP: neurotransmission in taste buds
Frontiers in Cellular Neuroscience, 2013 Not only is ATP a ubiquitous source of energy but it is also used widely as an intercellular signal. For example, keratinocytes release ATP in response to numerous external stimuli including pressure, heat and chemical insult. The released ATP activates
Thomas E. Finger, Sue C Kinnamon
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Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
eLife, 2020 ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured human ...
Hiromi Imamura +8 more
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Frontiers in Cellular Neuroscience, 2019 Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
Carolina E. Chávez +6 more
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Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020 Introduction: Diabetes is one of the most common metabolic diseases that is associated with high blood sugar and can cause disorders of the central nervous system.
Mohammad Rami +3 more
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Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
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Physiological ReportsWe sought to determine the physiological relevance of pannexin/purinergic‐dependent signaling in mediating conducted vasodilation elicited by capillary stimulation through skeletal muscle contraction.
Iain R. Lamb +2 more
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The biochemistry and function of pannexin channels
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Three family members compose the pannexin family of channel-forming glycoproteins (Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single-membrane channels that are regulated by post-translational modifications, channel intermixing, and sub-cellular expression profiles.
Penuela, Silvia +2 more
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The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
Frontiers in Cellular Neuroscience, 2017 Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to
Farraj Albalawi +9 more
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IMPLICATIONS OF PANNEXIN 1 AND PANNEXIN 3 IN KERATINOCYTE DIFFERENTIATION [PDF]
, 2009 Pannexin (Panx) 1 and Panx3 are integral membrane proteins with sequence homology to the invertebrate gap junctions, innexins, and are expressed in mammalian skin. Panxs form functional single-membrane channels but their importance in regulating cellular function is poorly understood.
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Pannexin 1 and Adipose Tissue [PDF]
, 2017 Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides and nucleosides are important regulators of adipocyte function, but the pathway for controlled ATP release from adipocytes is unknown. Here, we investigated whether Pannexin 1 (Panx1)
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