Results 1 to 10 of about 1,521 (154)
Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms [PDF]
Nature CommunicationsPannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain +7 more
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Pharmacology of pannexin channels. [PDF]
Curr Opin Pharmacol, 2023 Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the ability to pharmacologically block these channels is a vital component of several therapeutic approaches.
Koval M, Schug WJ, Isakson BE.
europepmc +3 more sources
ATP-release pannexin channels are gated by lysophospholipids [PDF]
eLifeIn addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze +11 more
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Human stem cells express pannexins [PDF]
BMC Research Notes, 2018 Objective Pannexins are channel proteins important for the release of calcium and adenosine triphosphate, which are among other functions involved in early development.
Nadine Hainz +6 more
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Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate [PDF]
Scientific ReportsMembrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of ...
Makoto Hosoya +6 more
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Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells [PDF]
Frontiers in Neuroscience, 2023 IntroductionThe subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals.
Enrique Jiménez-Madrona +8 more
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The Pannexins: Past and Present [PDF]
Frontiers in Physiology, 2014 The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Steven eBond +2 more
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Pannexins in the vasculature. [PDF]
Am J Physiol Heart Circ PhysiolPannexins (PANX1, PANX2, PANX3) are a family of large-pore, ion and metabolite channels present throughout the blood and lymphatic vascular networks. PANX1 has near-ubiquitous expression in the cardiovascular system and is the most highly studied pannexin in both homeostatic and disease conditions.
O'Donnell BL +6 more
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Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury [PDF]
Biomedicines, 2022 Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants still died or ...
Alice McDouall +5 more
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Identification of Pannexins in Rat Nasal Mucosa
Allergy & Rhinology, 2013 Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D. +7 more
doaj +3 more sources