Results 11 to 20 of about 1,521 (154)

Pannexin channels in the kidney. [PDF]

Am J Physiol Renal Physiol
Renal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney disease subtypes is incompletely understood; therefore, many patients progress to kidney failure, needing dialysis ...
Williams MD, O'Donnell BL, Columbus L, DeLalio LJ, Erdbrügger U, Isakson BE.   +5 more
europepmc   +2 more sources

Role of astrocytes connexins - pannexins in acute brain injury [PDF]

Neurotherapeutics
Acute brain injuries (ABIs) encompass a broad spectrum of primary injuries such as ischemia, hypoxia, trauma, and hemorrhage that converge into secondary injury where some mechanisms show common determinants.
Juan E. Tichauer, Maximiliano Rovegno
doaj   +2 more sources

Connexins, Pannexins, and Epilepsy

Abstract Connexins are proteins that form gap junctions which “connect” cells together, permitting the passage of small molecules and electricity. Since epilepsy is thought of as a disease of neuronal hypersynchrony, it is natural to consider these molecules with the gap junctions they form as playing a significant role in epilepsy. Over
Zhang L, Zoidl GR, Carlen PL.
europepmc   +2 more sources

Pannexin 1 Regulates Skeletal Muscle Regeneration by Promoting Bleb-Based Myoblast Migration and Fusion Through a Novel Lipid Based Signaling Mechanism

Frontiers in Cell and Developmental Biology, 2021
Adult skeletal muscle has robust regenerative capabilities due to the presence of a resident stem cell population called satellite cells. Muscle injury leads to these normally quiescent cells becoming molecularly and metabolically activated and embarking
Katia Suarez-Berumen, Katia Suarez-Berumen, Henry Collins-Hooper, Anastasia Gromova, Anastasia Gromova, Robyn Meech, Alessandra Sacco, Phil R. Dash, Robert Mitchell, Valery I. Shestopalov, Valery I. Shestopalov, Thomas E. Woolley, Sakthivel Vaiyapuri, Ketan Patel, Helen P. Makarenkova   +14 more
doaj   +1 more source

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation [PDF]

Journal of Cell Science, 2010
Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In
Steven J, Celetti, Kyle N, Cowan, Silvia, Penuela, Qing, Shao, Jared, Churko, Dale W, Laird   +5 more
openaire   +2 more sources

Gap junctions, pannexins and pain [PDF]

Neuroscience Letters, 2019
Enhanced expression and function of gap junctions and pannexin (Panx) channels have been associated with both peripheral and central mechanisms of pain sensitization. At the level of the sensory ganglia, evidence includes augmented gap junction and pannexin1 expression in glial cells and neurons in inflammatory and neuropathic pain models and increased
David C, Spray, Menachem, Hanani
openaire   +2 more sources

Are there gap junctions without connexins or pannexins?

BMC Evolutionary Biology, 2019
Background Gap junctions (GJ) are one of the most common forms of intercellular communication. GJs are assembled from proteins that form channels connecting the cytoplasm of adjacent cells.
Georgy A. Slivko-Koltchik, Victor P. Kuznetsov, Yuri V. Panchin   +2 more
doaj   +1 more source

Pannexins in Acute Kidney Injury [PDF]

Nephron, 2019
Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently effluxes ATP and plays a central role in the progression of inflammatory ...
Nabin, Poudel, Mark D, Okusa
openaire   +2 more sources

A review of the current state of pannexin channels as they relate to the blood vessel wall

Journal of Medical Sciences, 2017
Pannexin proteins comprise a family of channels whose sole function, to date, is the release of nucleotides (e.g., adenosine 5'-triphosphate [ATP] and uridine 5′-triphosphate [UTP]).
Brant E Isakson
doaj   +1 more source

Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization [PDF]

Cell Communication & Adhesion, 2013
Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking. Panx2, another family member, has a longer and highly dissimilar C-terminus.
Leigh E, Wicki-Stordeur, Andrew K J, Boyce, Leigh Anne, Swayne   +2 more
openaire   +2 more sources