Results 41 to 50 of about 1,521 (154)
The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition
eLife, 2020 Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins ...
Kevin Michalski +5 more
doaj +1 more source
Posttranslational Modifications in Connexins and Pannexins [PDF]
The Journal of Membrane Biology, 2012 Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function.
Johnstone, Scott +4 more
openaire +3 more sources
The Neuroglial Dialog Between Cannabinoids and Hemichannels
Frontiers in Molecular Neuroscience, 2018 The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules ...
Valeria C. Labra +11 more
doaj +1 more source
Emerging functions of Pannexin 1 in the eye
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
doaj +1 more source
Cancer Science, EarlyView.Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda +2 more
wiley +1 more source
Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury
Frontiers in Molecular Neuroscience, 2019 Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial activation and neuroinflammation in the retina. Glial activation and release of pro-inflammatory cytokines TNFα and IL-1β, complement, and other danger factors was ...
Alexey Pronin +11 more
doaj +1 more source
Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?
Frontiers in Physiology, 2022 The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male infertility has lately received significant attention. SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) in humans, has been shown to impose adverse effects
Temidayo S. Omolaoye +4 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm +3 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2018 A mounting body of evidence indicates that adolescents are specially more susceptible to alcohol influence than adults. However, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez +13 more
doaj +1 more source
Connexins, Innexins, and Pannexins: From Biology to Clinical Targets
Biomolecules, 2021 In 1964, Loewenstein and Kanno [...]
Trond Aasen
doaj +1 more source