Results 21 to 30 of about 2,203,634 (375)
Fragment synthesis of disulfide-containing peptides
MethodsX, 2020 A new strategy for solid phase peptide synthesis in the fragment synthesis based on the use of 2-Cl-trityl resin as carrier to obtain protected peptide-resin and Rink Amide Resin, HOBT/HBTU or PyBOP/DIPEA or HATU/DIPEA as the coupling method is described. The highlights of this method are:•Simple.•Low cost.•Solid phase based.
Hai Qian +3 more
openaire +3 more sources
Active Transport of Peptides Across the Intact Human Tympanic Membrane. [PDF]
, 2018 We previously identified peptides that are actively transported across the intact tympanic membrane (TM) of rats with infected middle ears. To assess the possibility that this transport would also occur across the human TM, we first developed and ...
Alexander, Thomas +9 more
core +1 more source
Folding propensities of peptide fragments of myoglobin [PDF]
Protein Science, 1997 Myoglobin has been studied extensively as a paradigm for protein folding. As part of an ongoing study of potential folding initiation sites in myoglobin, we have synthetized a series of peptides covering the entire sequence of sperm whale myoglobin. We report here on the conformation preferences of a series of peptides that cover the region from the A ...
M T Reymond +3 more
openaire +3 more sources
From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs
Frontiers in Pharmacology, 2019 The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin ...
Elena V. Kryukova +11 more
doaj +1 more source
A Dynamic Programming Approach to De Novo Peptide Sequencing via Tandem Mass Spectrometry [PDF]
, 2001 The tandem mass spectrometry fragments a large number of molecules of the same peptide sequence into charged prefix and suffix subsequences, and then measures mass/charge ratios of these ions.
Chen, Ting +4 more
core +3 more sources
Evolutionary Bioinformatics, 2021 A high level of mutation enables the influenza A virus to resist antibiotics previously effective against the influenza A virus. A portion of the structure of hemagglutinin HA is assumed to be well-conserved to maintain its role in cellular fusion, and ...
Hoa Thanh Le, Phuc-Chau Do, Ly Le
doaj +1 more source
Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides [PDF]
, 2010 Previously we have shown that the presence of 3-nitrotyrosine within a peptide sequence severely depletes the peptide backbone fragments typically observed following electron capture dissociation (ECD) mass spectrometry. Instead, ECD of nitrated peptides
Andrew W. Jones +30 more
core +2 more sources
Simultaneous and Traceless Ligation of Peptide Fragments on DNA Scaffold.
Biomacromolecules, 2019 Peptide ligation is an indispensable step in the chemical synthesis of target peptides and proteins that are difficult to synthesize at once by a solid-phase synthesis.
Gosuke Hayashi +3 more
semanticscholar +1 more source
Molecular basis for passive immunotherapy of Alzheimer's disease [PDF]
, 2007 Amyloid aggregates of the amyloid-{beta} (A{beta}) peptide are implicated in the pathology of Alzheimer's disease. Anti-A{beta} monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.
A. S. Gardberg +39 more
core +3 more sources
Proteomes, 2021 Non-invasive urinary peptide biomarkers are able to detect and predict chronic kidney disease (CKD). Moreover, specific urinary peptides enable discrimination of different CKD etiologies and offer an interesting alternative to invasive kidney biopsy ...
Lorenzo Catanese +6 more
doaj +1 more source