Results 11 to 20 of about 49,701 (247)

The pore conformation of lymphocyte perforin [PDF]

Science Advances, 2021
AbstractPerforin is a pore-forming protein that facilitates rapid killing of pathogen-infected or cancerous cells by the immune system. Perforin is released from cytotoxic lymphocytes, together with pro-apoptotic granzymes, to bind to the plasma membrane of the target cell where it oligomerises and forms pores.
Marina E. Ivanova, Natalya Lukoyanova, Sony Malhotra, Maya Topf, Joseph A. Trapani, Ilia Voskoboinik, Helen R. Saibil   +6 more
openaire   +7 more sources

Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis.

PLoS Biology, 2021
Natural killer (NK) cells kill a target cell by secreting perforin into the lytic immunological synapse, a specialized interface formed between the NK cell and its target.
Yu Li, Jordan S Orange
doaj   +2 more sources

Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway. [PDF]

PLoS ONE, 2018
The immune system plays a significant role in urothelial bladder cancer (UBC) progression, with CD8+ T cells being capable to directly kill tumor cells using perforin and granzymes. However, tumors avoid immune recognition by escape mechanisms.
Ciputra Adijaya Hartana, Emma Ahlén Bergman, A Ali Zirakzadeh, David Krantz, Malin E Winerdal, Max Winerdal, Markus Johansson, Farhood Alamdari, Tomasz Jakubczyk, Hans Glise, Katrine Riklund, Amir Sherif, Ola Winqvist   +12 more
doaj   +2 more sources

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

eLife, 2015
Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication
Ryan M McCormack, Lesley R de Armas, Motoaki Shiratsuchi, Desiree G Fiorentino, Melissa L Olsson, Mathias G Lichtenheld, Alejo Morales, Kirill Lyapichev, Louis E Gonzalez, Natasa Strbo, Neelima Sukumar, Olivera Stojadinovic, Gregory V Plano, George P Munson, Marjana Tomic-Canic, Robert S Kirsner, David G Russell, Eckhard R Podack   +17 more
doaj   +2 more sources

Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

eLife, 2015
Perforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria.
Ryan M McCormack, Kirill Lyapichev, Melissa L Olsson, Eckhard R Podack, George P Munson   +4 more
doaj   +2 more sources

Adenosine leakage from perforin-burst extracellular vesicles inhibits perforin secretion by cytotoxic T-lymphocytes

PLOS ONE, 2020
Extracellular vesicles (EVs) in the tumor microenvironment facilitate intercellular communication. Cancer cell-derived EVs act as an immunosuppressor by transporting cargos and presenting transmembrane proteins. By contrast, CD8+ cytotoxic T-lymphocytes (CTLs) exert anti-cancer cytotoxicity via the pore-forming protein perforin.
Hiroko Tadokoro, Akiyoshi Hirayama, Ryuhei Kudo, Masako Hasebe, Yusuke Yoshioka, Juntaro Matsuzaki, Yusuke Yamamoto, Masahiro Sugimoto, Tomoyoshi Soga, Takahiro Ochiya   +9 more
openaire   +5 more sources

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

bioRxiv, 2023
During initiation of antiviral and antitumour T cell-mediated immune responses, dendritic cells (DCs) cross-present exogenous antigens on MHC class I.
Pablo Rodríguez-Silvestre, Marco Laub, A. Davies, J. Schessner, Patrycja A. Krawczyk, Benjamin J. Tuck, W. McEwan, Georg H. H. Borner, Patrycja Kozik   +8 more
semanticscholar   +1 more source

Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to Perforin-2 suppression.

Journal of Clinical Investigation, 2021
Impaired wound healing associated with recurrent Staphylococcus aureus infection and unresolved inflammation are hallmarks of non-healing diabetic foot ulcers (DFU). Perforin-2, an innate immunity molecule against intracellular bacteria, limits cutaneous
I. Pastar, A. Sawaya, J. Marjanović, J. Burgess, N. Strbo, K. Rivas, T. Wikramanayake, Cheyanne R. Head, Rivka C. Stone, I. Jozic, Olivera Stojadinović, Eran Y. Kornfeld, R. Kirsner, H. Lev-Tov, M. Tomic‐Canic   +14 more
semanticscholar   +1 more source

Gold Nanoparticles and Graphene Oxide Flakes Enhance Cancer Cells’ Phagocytosis through Granzyme-Perforin-Dependent Biomechanism

Nanomaterials, 2021
The study aimed to investigate the roles of gold nanoparticles (GNPs) and graphene oxide flakes (GOFs) as phagocytosis enhancers against cancer cells. The nanomaterials were characterized through SEM and UV-VIS absorptions.
Mohsen S. Al-Omar, M. Jabir, Esraa H. Karsh, Rua J. Kadhim, G. Sulaiman, Z. Taqi, K. Khashan, H. Mohammed, Riaz A. Khan, Salman A. A. Mohammed   +9 more
semanticscholar   +1 more source

Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Science Advances, 2020
Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack. Perforin-2 (MPEG1) is thought to enable the killing of invading microbes engulfed by macrophages and other phagocytes, forming ...
T. Ni, Fang Jiao, Xiulian Yu, Saša Aden, L. Ginger, Sophie I. Williams, Fangfang Bai, V. Pražák, D. Karia, P. Stansfeld, Peijun Zhang, George Munson, G. Anderluh, S. Scheuring, Robert C. G. Gilbert   +14 more
semanticscholar   +1 more source